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J. Biol. Chem., Vol. 278, Issue 52, 51989-51992, December 26, 2003

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ACCELERATED PUBLICATIONS

Deubiquitination, a New Player in Golgi to Endoplasmic Reticulum Retrograde Transport^*

Mickaël Cohen, Françoise Stutz¶, and Catherine Dargemont||

From the Nucleocytoplasmic transport group, Institut Jacques Monod, Unité Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 Place Jussieu, Tour 43, 75251 Paris Cedex 05, France and the ^¶Department of Cell Biology, Sciences III, 30 Quai E, Ansermet, 1211 Genève 4, Switzerland

Modification by ubiquitin plays a major role in a broad array of cellular functions. Although reversal of this process, deubiquitination, likely represents an important regulatory step contributing to cellular homeostasis, functions of deubiquitination enzymes still remain poorly characterized. We have previously shown that the ubiquitin protease Ubp3p requires a co-factor, Bre5p, to specifically deubiquitinate the coat protein complex II (COPII) subunit Sec23p, which is involved in anterograde transport between endoplasmic reticulum and Golgi compartiments. In the present report, we show that disruption of BRE5 gene also led to a defect in the retrograde transport from the Golgi to the endoplasmic reticulum. Further analysis indicate that the COPI subunit '-COP represents another substrate of the Ubp3p·Bre5p complex. All together, our results indicate that the Ubp3p·Bre5p deubiquitination complex co-regulates anterograde and retrograde transports between endoplasmic reticulum and Golgi compartments.

Received for publication, October 16, 2003 , and in revised form, October 29, 2003.

^* This work was supported by grants from the Association de Recherche contre le Cancer and the Ligue contre le Cancer. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Fellow from the Association de Recherche contre le Cancer.

^|| To whom correspondence should be addressed: Inst. Jacques Monod, Unité Mixte de Recherche 7592, CNRS, Universités Paris VI and VII, 2 Place Jussieu, Tour 43, 75251 Paris Cedex 05, France. Tel./Fax: 33-1-44276956; E-mail: dargemont{at}ijm.jussieu.fr.

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