Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M205616200 on November 21, 2002

J. Biol. Chem., Vol. 278, Issue 6, 3969-3975, February 7, 2003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
278/6/3969    most recent
M205616200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pikkarainen, S.
Right arrow Articles by Ruskoaho, H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pikkarainen, S.
Right arrow Articles by Ruskoaho, H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Endothelin-1-specific Activation of B-type Natriuretic Peptide Gene via p38 Mitogen-activated Protein Kinase and Nuclear ETS Factors*

Sampsa PikkarainenDagger , Heikki TokolaDagger , Risto KerkeläDagger , Theresa Majalahti-Palviainen§, Olli Vuolteenaho§, and Heikki RuskoahoDagger

From the Dagger  Department of Pharmacology and Toxicology and § Department of Physiology, Biocenter Oulu, University of Oulu, P. O. Box 5000, Oulu FIN-90014, Finland

Terminally differentiated cardiac myocytes adapt to mechanical and neurohumoral stress via morphological changes of individual cells accompanied by reactivation of fetal pattern of gene expression. Endothelin-1, a powerful paracrine mediator of myocyte growth, induces similar changes in cultured cardiac myocytes as those seen in hypertrophied heart in vivo. By using rat B-type natriuretic peptide promoter, we identified a novel ETS binding sequence, on which nuclear protein binding is activated in endothelin-1-treated cultured cardiac myocytes. This sequence binds ETS-like gene-1 transcription factor and mediates endothelin-1-specific activation of transcription, but not responses to increased calcium signaling via L-type calcium channels, angiotensin II treatment, or mechanical stretch of myocytes. Interestingly, endothelin-1 activated signaling converges via p38 mitogen-activated protein kinase-dependent mechanism on ETS binding site, whereas this element inhibits extracellular signal-regulated kinase activated transcription. In conclusion, given the fundamental role of the interaction of mitogen-activated protein kinases and ETS factors in regulation of eukaryotic cell differentiation, growth, and oncogenesis, these results provide the unique evidence of a endothelin-1- and mitogen-activated protein kinase-regulated ETS factor pathway for cardiac myocytes.

* This work was supported by grants from the Academy of Finland (to H. R.), the AstraZeneca Research Foundation (to S. P.), the Sigrid Juselius Foundation (to H. R.), the Aarne Koskelo Foundation (to R. K., T. M.-P., and S. P.), the Ida Montin Foundation (to R. K. and S. P.), the Finnish Foundation for Cardiovascular Research (to H. R., S. P., and R. K.), the Research Foundation of Orion Co. (to R. K.), and the Finnish Cultural Foundation (to S. P.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Tel.: 358-8-537-5236; Fax: 358-8-537-5247; E-mail: heikki.ruskoaho@oulu.fi.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
A. J. Bingham, L. Ooi, L. Kozera, E. White, and I. C. Wood
The Repressor Element 1-Silencing Transcription Factor Regulates Heart-Specific Gene Expression Using Multiple Chromatin-Modifying Complexes
Mol. Cell. Biol., June 1, 2007; 27(11): 4082 - 4092.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. G. Gardner, S. Chen, D. J. Glenn, and C. L. Grigsby
Molecular Biology of the Natriuretic Peptide System: Implications for Physiology and Hypertension
Hypertension, March 1, 2007; 49(3): 419 - 426.
[Full Text] [PDF]

Home page
 J. Lipid Res.Home page
G. Foldes, S. Vajda, Z. Lako-Futo, B. Sarman, R. Skoumal, M. Ilves, R. deChatel, I. Karadi, M. Toth, H. Ruskoaho, et al.
Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type
J. Lipid Res., June 1, 2006; 47(6): 1219 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. Pikkarainen, H. Tokola, R. Kerkela, M. Ilves, M. Makinen, H.-D. Orzechowski, M. Paul, O. Vuolteenaho, and H. Ruskoaho
Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1beta genes in cardiac cells by mechanical load
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2006; 290(6): R1639 - R1645.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
S. Pikkarainen, H. Tokola, R. Kerkela, and H. Ruskoaho
GATA transcription factors in the developing and adult heart
Cardiovasc Res, August 1, 2004; 63(2): 196 - 207.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Pikkarainen, H. Tokola, T. Majalahti-Palviainen, R. Kerkela, N. Hautala, S. S. Bhalla, F. Charron, M. Nemer, O. Vuolteenaho, and H. Ruskoaho
GATA-4 Is a Nuclear Mediator of Mechanical Stretch-activated Hypertrophic Program
J. Biol. Chem., June 20, 2003; 278(26): 23807 - 23816.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement