Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M211132200 on December 17, 2002

J. Biol. Chem., Vol. 278, Issue 8, 6575-6579, February 21, 2003
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
278/8/6575    most recent
M211132200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Schwindinger, W. F.
Right arrow Articles by Robishaw, J. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Schwindinger, W. F.
Right arrow Articles by Robishaw, J. D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Loss of G Protein gamma 7 Alters Behavior and Reduces Striatal alpha olf Level and cAMP Production*

William F. SchwindingerDagger , Kelly S. BetzDagger , Kathryn E. GigerDagger , Angela SabolDagger , Sarah K. Bronson§, and Janet D. RobishawDagger

From the Dagger  Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822 and the § Department of Cellular and Molecular Physiology, The Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033-0850

The G protein beta gamma -dimer is required for receptor interaction and effector regulation. However, previous approaches have not identified the physiologic roles of individual subtypes in these processes. We used a gene knockout approach to demonstrate a unique role for the G protein gamma 7-subunit in mice. Notably, deletion of Gng7 caused behavioral changes that were associated with reductions in the alpha olf-subunit content and adenylyl cyclase activity of the striatum. These data demonstrate that an individual gamma -subunit contributes to the specificity of a given signaling pathway and controls the formation or stability of a particular G protein heterotrimer.

* This work was supported by National Institutes of Health Grant GM39867 (to J. D. R.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Weis Center for Research, Geisinger Clinic, 100 North Academy Ave., Danville, PA 17822. Tel.: 570-271-6684; Fax: 570-271-6701; E-mail: jrobishaw@geisinger.edu.

Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Neurosci.Home page
E. S. Lobanova, S. Finkelstein, R. Herrmann, Y.-M. Chen, C. Kessler, N. A. Michaud, L. H. Trieu, K. J. Strissel, M. E. Burns, and V. Y. Arshavsky
Transducin {gamma}-Subunit Sets Expression Levels of {alpha}- and {beta}-Subunits and Is Crucial for Rod Viability
J. Neurosci., March 26, 2008; 28(13): 3510 - 3520.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. N. Nikolov and T. T. Ivanova-Nikolova
Dynamic Integration of {alpha}-Adrenergic and Cholinergic Signals in the Atria: ROLE OF G PROTEIN-REGULATED INWARDLY RECTIFYING K+ CHANNELS
J. Biol. Chem., September 28, 2007; 282(39): 28669 - 28682.
[Abstract] [Full Text] [PDF]

Home page
 Genome ResHome page
V. A. Petyuk, W.-J. Qian, M. H. Chin, H. Wang, E. A. Livesay, M. E. Monroe, J. N. Adkins, N. Jaitly, D. J. Anderson, D. G. Camp II, et al.
Spatial mapping of protein abundances in the mouse brain by voxelation integrated with high-throughput liquid chromatography-mass spectrometry
Genome Res., March 1, 2007; 17(3): 328 - 336.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. M. Mervine, E. A. Yost, J. L. Sabo, T. R. Hynes, and C. H. Berlot
Analysis of G Protein beta{gamma} Dimer Formation in Live Cells Using Multicolor Bimolecular Fluorescence Complementation Demonstrates Preferences of beta1 for Particular {gamma} Subunits
Mol. Pharmacol., July 1, 2006; 70(1): 194 - 205.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. Leung, H. Chen, A. M. Stauffer, K. E. Giger, S. Sinha, E. J. Horstick, J. E. Humbert, C. A. Hansen, and J. D. Robishaw
Zebrafish G protein {gamma}2 is required for VEGF signaling during angiogenesis
Blood, July 1, 2006; 108(1): 160 - 166.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C.-S. Myung, W. K. Lim, J. M. DeFilippo, H. Yasuda, R. R. Neubig, and J. C. Garrison
Regions in the G Protein {gamma} Subunit Important for Interaction with Receptors and Effectors
Mol. Pharmacol., March 1, 2006; 69(3): 877 - 887.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. Krystofova and K. A. Borkovich
The Heterotrimeric G-Protein Subunits GNG-1 and GNB-1 Form a G{beta}{gamma} Dimer Required for Normal Female Fertility, Asexual Development, and G{alpha} Protein Levels in Neurospora crassa
Eukaryot. Cell, February 1, 2005; 4(2): 365 - 378.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. R. Kerchner, R. L. Clay, G. McCleery, N. Watson, W. E. McIntire, C.-S. Myung, and J. C. Garrison
Differential Sensitivity of Phosphatidylinositol 3-Kinase p110{gamma} to Isoforms of G Protein {beta}{gamma} Dimers
J. Biol. Chem., October 22, 2004; 279(43): 44554 - 44562.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. R. Hynes, S. M. Mervine, E. A. Yost, J. L. Sabo, and C. H. Berlot
Live Cell Imaging of Gs and the {beta}2-Adrenergic Receptor Demonstrates That Both {alpha}s and {beta}1{gamma}7 Internalize upon Stimulation and Exhibit Similar Trafficking Patterns That Differ from That of the {beta}2-Adrenergic Receptor
J. Biol. Chem., October 15, 2004; 279(42): 44101 - 44112.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. F. Schwindinger, K. E. Giger, K. S. Betz, A. M. Stauffer, E. M. Sunderlin, L. J. Sim-Selley, D. E. Selley, S. K. Bronson, and J. D. Robishaw
Mice with Deficiency of G Protein {gamma}3 Are Lean and Have Seizures
Mol. Cell. Biol., September 1, 2004; 24(17): 7758 - 7768.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J.-C. Corvol, M.-P. Muriel, E. Valjent, J. Feger, N. Hanoun, J.-A. Girault, E. C. Hirsch, and D. Herve
Persistent Increase in Olfactory Type G-Protein {alpha} Subunit Levels May Underlie D1 Receptor Functional Hypersensitivity in Parkinson Disease
J. Neurosci., August 4, 2004; 24(31): 7007 - 7014.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Interv.Home page
M. B. Jones, D. P. Siderovski, and S. B. Hooks
The G{beta}{gamma} DIMER as a NOVEL SOURCE of SELECTIVITY in G-Protein Signaling: GGL-ing AT CONVENTION
Mol. Interv., August 1, 2004; 4(4): 200 - 214.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. R. Hynes, L. Tang, S. M. Mervine, J. L. Sabo, E. A. Yost, P. N. Devreotes, and C. H. Berlot
Visualization of G Protein {beta}{gamma} Dimers Using Bimolecular Fluorescence Complementation Demonstrates Roles for Both {beta} and {gamma} in Subcellular Targeting
J. Biol. Chem., July 16, 2004; 279(29): 30279 - 30286.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2003 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement