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J. Biol. Chem., Vol. 278, Issue 9, 7397-7405, February 28, 2003
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From the Department of Biological Sciences, Korea Advanced
Institute of Science and Technology, Daejeon 305-701, Korea
Latency-associated nuclear antigen (LANA) of
Kaposi's sarcoma-associated herpesvirus plays an important role in
maintenance of the viral genome during latent infection. LANA
additionally participates in the transcriptional regulation of several
viral and cellular promoters. When tethered to constitutively active promoters, the protein exhibits transcriptional repressor activity. In
this report, we further characterized cell type-, promoter-, and
domain-specific transcriptional repression by LANA. We additionally speculated on the mechanism underlying transcriptional repression by
the C terminus of the protein. Subnuclear localization patterns and
association with heterochromatin suggested a possible link between LANA
and heterochromatin protein 1, a representative
heterochromatin-associated protein. In vivo and in
vitro binding and immunofluorescence assays revealed that LANA
associates with heterochromatin protein 1 in an isotype-specific
manner. Furthermore, biochemical fractionation and transient
replication assays supported the possibility that this interaction
contributes to transcriptional repression, targeting to subnuclear
structures, and latent DNA replication activity of LANA.
Latency-associated Nuclear Antigen of Kaposi's
Sarcoma-associated Herpesvirus Functionally Interacts with
Heterochromatin Protein 1*
*
This work was supported in part by grants from the National
Research Laboratory Program of the Korea Institute of Science and
Technology Evaluation and Planning, the Korea Science and Engineering
Foundation through the Protein Network Research Center at Yonsei
University, and the BK21 Program of the Ministry of Education, Korea.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.: 82-42-869-2630;
Fax: 82-42-869-5630; E-mail: jchoe@mail.kaist.ac.kr.
Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
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