|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 278, Issue 9, 7617-7623, February 28, 2003
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Cell adhesion to the extracellular matrix
influences many cellular functions. The integrin family of matrix
receptors plays major roles in the formation of adhesions, but other
proteins modulate integrin signaling. Syndecan-4, a transmembrane
proteoglycan, cooperatively signals with integrins during the formation
of focal adhesions. To date, a direct link between syndecan-4 and the
cytoskeleton has remained elusive. We now demonstrate by Triton X-100
extraction immunoprecipitation and in vitro binding assays
that the focal adhesion component
Syndecan-4 Associates with
-Actinin*
,
Department of Cell Biology, University of
Alabama, Birmingham, Alabama 35294-0006, § Department of
Bioscience, University of Helsinki, Helsinki FIN-00014, Finland, and
¶ Cell and Molecular Biology Division, Division of Biomedical
Sciences, Imperial College, London SW7 2AZ, United Kingdom
-actinin interacts with syndecan-4
in a 
-integrin-independent manner.
*
This study was supported by National Institutes of Health
Grant GM50194 (to A. W.) and by Sankyo, Co., Ltd.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: Dept. of Cell
Biology, THT 946, University of Alabama, 1530 3rd Ave. S., Birmingham, AL 35294-0006. Tel.: 205-934-1548; Fax: 205-934-7029; E-mail: anwoods@uab.edu.
Copyright © 2003 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Scarpellini, R. Germack, H. Lortat-Jacob, T. Muramatsu, E. Billett, T. Johnson, and E. A. M. Verderio Heparan Sulfate Proteoglycans Are Receptors for the Cell-surface Trafficking and Biological Activity of Transglutaminase-2 J. Biol. Chem., July 3, 2009; 284(27): 18411 - 18423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Whiteford, S. Ko, W. Lee, and J. R. Couchman Structural and Cell Adhesion Properties of Zebrafish Syndecan-4 Are Shared with Higher Vertebrates J. Biol. Chem., October 24, 2008; 283(43): 29322 - 29330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. C. Dews and K. R. MacKenzie Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions PNAS, December 26, 2007; 104(52): 20782 - 20787. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Whiteford and J. R. Couchman A Conserved NXIP Motif Is Required for Cell Adhesion Properties of the Syndecan-4 Ectodomain J. Biol. Chem., October 27, 2006; 281(43): 32156 - 32163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bjornson Granqvist, K. Ebefors, M. A. Saleem, P. W. Mathieson, B. Haraldsson, and J. S. Nystrom Podocyte proteoglycan synthesis is involved in the development of nephrotic syndrome Am J Physiol Renal Physiol, October 1, 2006; 291(4): F722 - F730. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dovas, A. Yoneda, and J. R. Couchman PKC{alpha}-dependent activation of RhoA by syndecan-4 during focal adhesion formation J. Cell Sci., July 1, 2006; 119(13): 2837 - 2846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Filla, A. Woods, P. L. Kaufman, and D. M. Peters {beta}1 and {beta}3 Integrins Cooperate to Induce Syndecan-4-Containing Cross-linked Actin Networks in Human Trabecular Meshwork Cells Invest. Ophthalmol. Vis. Sci., May 1, 2006; 47(5): 1956 - 1967. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Choi, E. Lee, S. Kwon, H. Park, J. Y. Yi, S. Kim, I.-O. Han, Y. Yun, and E.-S. Oh Transmembrane Domain-induced Oligomerization Is Crucial for the Functions of Syndecan-2 and Syndecan-4 J. Biol. Chem., December 30, 2005; 280(52): 42573 - 42579. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Chaudhuri, S. M. Colles, P. L. Fox, and L. M. Graham Protein Kinase C{delta}-Dependent Phosphorylation of Syndecan-4 Regulates Cell Migration Circ. Res., September 30, 2005; 97(7): 674 - 681. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Powner, R. M. Payne, T. R. Pettitt, M. L. Giudici, R. F. Irvine, and M. J. O. Wakelam Phospholipase D2 stimulates integrin-mediated adhesion via phosphatidylinositol 4-phosphate 5-kinase I{gamma}b J. Cell Sci., July 1, 2005; 118(13): 2975 - 2986. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. S. Fraley, C. B. Pereira, T. C. Tran, C. Singleton, and J. A. Greenwood Phosphoinositide Binding Regulates {alpha}-Actinin Dynamics: MECHANISM FOR MODULATING CYTOSKELETAL REMODELING J. Biol. Chem., April 15, 2005; 280(15): 15479 - 15482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tkachenko, J. M. Rhodes, and M. Simons Syndecans: New Kids on the Signaling Block Circ. Res., March 18, 2005; 96(5): 488 - 500. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Tkachenko, E. Lutgens, R.-V. Stan, and M. Simons Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway J. Cell Sci., July 1, 2004; 117(15): 3189 - 3199. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |