Originally published In Press as doi:10.1074/jbc.R300038200 on February 11, 2004
J. Biol. Chem., Vol. 279, Issue 13, 12001-12004, March 26, 2004
Minireview
Integrins in Mechanotransduction*
Akira Katsumi
,
A. Wayne Orr,
Eleni Tzima¶, and
Martin Alexander Schwartz||**
From the
Cardiovascular Research Center and ||Departments of Microbiology and Biomedical Engineering and Mellon Prostate Cancer Institute, University of Virginia, Charlottesville, Virginia 22908 and ¶Department of Cell Biology, Scripps Research Institute, La Jolla, California 99037
Mechanical forces are crucial to the regulation of cell and tissue morphology and function. At the cellular level, forces influence cytoskeletal organization, gene expression, proliferation, and survival. Integrin-mediated adhesions are intrinsically mechanosensitive and a large body of data implicates integrins in sensing mechanical forces. We review the relationship between integrins and mechanical forces, the role of integrins in cellular responses to stretch and fluid flow, and propose that some of these events are mechanistically related.
* This minireview will be reprinted in the 2004 Minireview Compendium, which will be available in January, 2005. This work was supported by American Heart Association Grants 0325124Y (to E. T.) and 0325654U (to A. W. O.) and National Institutes of Health Grants RO1 HL075092 and RO1 GM47214 (to M. A. S.).
These three authors contributed equally and are listed in alphabetical order.
** To whom correspondence should be addressed. E-mail: maschwartz{at}virginia.edu.
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