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J. Biol. Chem., Vol. 279, Issue 24, 25927-25934, June 11, 2004

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Molecular Cloning and Functional Characterization of the Transcription Factor YY2^*

Nang Nguyen, Xiaohong Zhang¶, Nancy Olashaw¶, and Edward Seto¶||

From the Department of Medical Microbiology & Immunology, College of Medicine and ^¶H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612

YY1 is a ubiquitous zinc finger transcription factor that binds to and regulates promoters and enhancers of many cellular and viral genes. Here we report the isolation of a human cDNA encoding a DNA sequence-specific binding protein with significant homology to the transcription factor YY1. A sequence analysis of this novel protein, YY2, revealed an overall 65% identity in the DNA sequence and a 56% identity in protein sequence compared with human YY1. The most pronounced similarity between YY1 and YY2 exists within the zinc finger regions of the two proteins, and consistent with this observation, YY2 can bind to and regulate some promoters known to be controlled by YY1. Similar to YY1, YY2 contains both transcriptional activation and repression functions. The finding of a protein with structure and function similar to YY1 provides a new opportunity to explore additional mechanisms by which YY1-responsive genes can be regulated and suggests that gene regulation by YY1 is far more complicated than previously assumed.

Received for publication, March 5, 2004 , and in revised form, April 6, 2004.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBank^TM/EBI Data Bank with accession number(s) AY567472.

^* This work is supported by National Institutes of Health Grant GM64850 and the Kaul Foundation (to E. S.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Recipient of an American Heart Association predoctoral fellowship.

^|| To whom correspondence should be addressed: H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr., Tampa, FL 33612. Tel.: 813-979-6754; Fax: 813-979-7264; E-mail: setoe{at}moffitt.usf.edu.

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