|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 279, Issue 28, 28880-28888, July 9, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and Invasion*
||
From the
Department of Pediatrics, The Whittier Institute, and Moores Comprehensive Cancer Center, University of California at San Diego, La Jolla, California 92037 and ¶Mount Zion Comprehensive Cancer Center, University of California, San Francisco, California 94143
The cell adhesion molecule L1 has been implicated in a variety of motile processes, including neurite extension, cerebellar cell migration, extravasation, and metastasis. Homophilic or heterophilic L1 binding and concomitant signaling have been shown to promote cell motility in the short term. In this report, L1 is also shown to induce and maintain a motile and invasive phenotype by promoting gene transcription. In the presence of serum or platelet-derived growth factor, L1 promotes heightened and sustained activation of the extracellular signal-regulated kinase pathway. Activation of this pathway then induces the expression of motility- and invasion-associated gene products, including the 
3-integrin subunit, small GTPases, and the cysteine proteases cathepsin-L and -B. Induction of integrin 
v3 and rac-1 is shown to contribute directly to L1-dependent haptotaxis, whereas induction of cathepsins-L and -B promotes matrix invasion. This study provides a novel translational mechanism to account for the association between L1 expression and motile processes involved in metastasis and development.
Received for publication, April 13, 2004 , and in revised form, May 5, 2004.
* This work was supported by NCI/National Institutes of Health RO1 Grant CA69112-01, NHLBI/National Institutes of Health RO1 Grant HL62477-01 (to A. M. P. M.), and NIDDK/National Institutes of Health R01 Grants DK55183 and DK55183S1 (to V. C.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
|| To whom correspondence should be addressed: Dept. of Pediatrics, The Whittier Institute, University of California at San Diego, 9894 Genesee Ave., La Jolla, CA 92037. Tel.: 858-550-2909; Fax: 858-558-3495; E-mail: ammontgo{at}ucsd.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  C. Geismann, M. Morscheck, D. Koch, F. Bergmann, H. Ungefroren, A. Arlt, M.-S. Tsao, M. G. Bachem, P. Altevogt, B. Sipos, et al. Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor {beta}1- and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer Cancer Res., May 15, 2009; 69(10): 4517 - 4526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Ivanova, C. M.V. Goparaju, S. V. Ivanov, D. Nonaka, C. Cruz, A. Beck, F. Lonardo, A. Wali, and H. I. Pass Protumorigenic Role of HAPLN1 and Its IgV Domain in Malignant Pleural Mesothelioma Clin. Cancer Res., April 15, 2009; 15(8): 2602 - 2611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M.-R. Du, W.-H. Zhou, L. Dong, X.-Y. Zhu, Y.-Y. He, J.-Y. Yang, and D.-J. Li Cyclosporin A Promotes Growth and Invasiveness In Vitro of Human First-Trimester Trophoblast Cells Via MAPK3/MAPK1-Mediated AP1 and Ca2+/Calcineurin/NFAT Signaling Pathways Biol Reprod, June 1, 2008; 78(6): 1102 - 1110. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-J. Boo, J.-M. Park, J. Kim, Y.-S. Chae, B.-W. Min, J.-W. Um, and H.-Y. Moon L1 Expression as a Marker for Poor Prognosis, Tumor Progression, and Short Survival in Patients with Colorectal Cancer Ann. Surg. Oncol., May 1, 2007; 14(5): 1703 - 1711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Chen, J. Wu, I. Apostolova, M. Skup, A. Irintchev, S. Kugler, and M. Schachner Adeno-associated virus-mediated L1 expression promotes functional recovery after spinal cord injury Brain, April 1, 2007; 130(4): 954 - 969. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Knogler, J. Grunberg, K. Zimmermann, S. Cohrs, M. Honer, S. Ametamey, P. Altevogt, M. Fogel, P. A. Schubiger, and I. Novak-Hofer Copper-67 Radioimmunotherapy and Growth Inhibition by Anti-L1-Cell Adhesion Molecule Monoclonal Antibodies in a Therapy Model of Ovarian Cancer Metastasis Clin. Cancer Res., January 15, 2007; 13(2): 603 - 611. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Szczur, H. Xu, S. Atkinson, Y. Zheng, and M.-D. Filippi Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils Blood, December 15, 2006; 108(13): 4205 - 4213. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-S. Wu, R. K. Tsai, C. H. Chang, S. Wang, J.-R. Wu, and Y.-X. Chang Reactive Oxygen Species Mediated Sustained Activation of Protein Kinase C {alpha} and Extracellular Signal-Regulated Kinase for Migration of Human Hepatoma Cell Hepg2 Mol. Cancer Res., October 1, 2006; 4(10): 747 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guo, J. Lu, A. Subramanian, and G. E. Sonenshein Microarray-Assisted Pathway Analysis Identifies Mitogen-Activated Protein Kinase Signaling as a Mediator of Resistance to the Green Tea Polyphenol Epigallocatechin 3-Gallate in Her-2/neu-Overexpressing Breast Cancer Cells. Cancer Res., May 15, 2006; 66(10): 5322 - 5329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J.E. Arlt, I. Novak-Hofer, D. Gast, V. Gschwend, G. Moldenhauer, J. Grunberg, M. Honer, P. A. Schubiger, P. Altevogt, and A. Kruger Efficient Inhibition of Intra-Peritoneal Tumor Growth and Dissemination of Human Ovarian Carcinoma Cells in Nude Mice by Anti-L1-Cell Adhesion Molecule Monoclonal Antibody Treatment Cancer Res., January 15, 2006; 66(2): 936 - 943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Conacci-Sorrell, A. Kaplan, S. Raveh, N. Gavert, T. Sakurai, and A. Ben-Ze'ev The Shed Ectodomain of Nr-CAM Stimulates Cell Proliferation and Motility, and Confers Cell Transformation Cancer Res., December 15, 2005; 65(24): 11605 - 11612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Maretzky, M. Schulte, A. Ludwig, S. Rose-John, C. Blobel, D. Hartmann, P. Altevogt, P. Saftig, and K. Reiss L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/{gamma}-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth Mol. Cell. Biol., October 15, 2005; 25(20): 9040 - 9053. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Gutwein, A. Stoeck, S. Riedle, D. Gast, S. Runz, T. P. Condon, A. Marme, M.-C. Phong, O. Linderkamp, A. Skorokhod, et al. Cleavage of L1 in Exosomes and Apoptotic Membrane Vesicles Released from Ovarian Carcinoma Cells Clin. Cancer Res., April 1, 2005; 11(7): 2492 - 2501. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gavert, M. Conacci-Sorrell, D. Gast, A. Schneider, P. Altevogt, T. Brabletz, and A. Ben-Ze'ev L1, a novel target of {beta}-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers J. Cell Biol., February 14, 2005; 168(4): 633 - 642. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Suzuki, S Izumoto, Y Fujimoto, M Maruno, Y Ito, and T Yoshimine Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion J. Clin. Pathol., February 1, 2005; 58(2): 166 - 171. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |