| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 279, Issue 30, 31973-31982, July 23, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
¶
From the
Laboratory of Immunogenetics, NIAID, National Institutes of Health, Rockville, Maryland 20852, the Department of Medicine and Microbiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, and the ||Memorial Sloan Kettering Cancer Center, Radiochemistry Core Facility, New York, New York 10021
Signaling through the B cell antigen receptor (BCR) is amplified and prolonged by coligation of the BCR to the CD19/CD21/CD81 coreceptor complex. Coligation is induced during immune responses by the simultaneous binding of complement-tagged antigens to the complement receptor, CD21, and to the BCR. Enhanced signaling is due in part to the ability of the CD19/CD21/CD81 complex to stabilize the BCR in sphingolipid- and cholesterol-rich membrane microdomains termed lipid rafts. The tetraspanin CD81 is essential for the raft-stabilizing function of the coreceptor. Here we show that coligation of the BCR and the CD19/CD21/CD81 complex leads to selective, rapid, and reversible palmitoylation of CD81 and that palmitoylation is necessary for the raft stabilizing function of the CD19/CD21/CD81 complex. Inducible palmitoylation may represent a novel mechanism by which tetraspanins function to facilitate lipid raft-dependent receptor signaling.
Received for publication, April 21, 2004 , and in revised form, May 24, 2004.
* The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
¶ Current address: Molecular Inflammation Section, NIAMS, NIH, Bethesda, MD 20892.
** Current address: M. D. Anderson Cancer Center, Houston, TX 77030.
To whom correspondence should be addressed: Laboratory of Immunogenetics, NIAID/NIH/Twinbrook II, 12441 Parklawn Dr., Rm. 200B, MSC 8180, Rockville, MD 20852. Tel.: 301-496-9589; Fax: 301-402-0259; E-mail: spierce{at}nih.gov.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Serra, S. Nuti, S. Tavarini, C. Sammicheli, D. Rosa, G. Saletti, E. Soldaini, S. Abrignani, and A. Wack Coligation of the Hepatitis C Virus Receptor CD81 with CD28 Primes Naive T Lymphocytes to Acquire Type 2 Effector Function J. Immunol., July 1, 2008; 181(1): 174 - 185. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Brown Lipid Rafts, Detergent-Resistant Membranes, and Raft Targeting Signals. Physiology, December 1, 2006; 21(6): 430 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. W. Sohn, P. Tolar, T. Jin, and S. K. Pierce Fluorescence resonance energy transfer in living cells reveals dynamic membrane changes in the initiation of B cell signaling PNAS, May 23, 2006; 103(21): 8143 - 8148. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. H. Yang, O. V. Kovalenko, T. V. Kolesnikova, M. M. Andzelm, E. Rubinstein, J. L. Strominger, and M. E. Hemler Contrasting Effects of EWI Proteins, Integrins, and Protein Palmitoylation on Cell Surface CD9 Organization J. Biol. Chem., May 5, 2006; 281(18): 12976 - 12985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bertaux and T. Dragic Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry. J. Virol., May 1, 2006; 80(10): 4940 - 4948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Shoham, R. Rajapaksa, C.-C. Kuo, J. Haimovich, and S. Levy Building of the Tetraspanin Web: Distinct Structural Domains of CD81 Function in Different Cellular Compartments Mol. Cell. Biol., February 15, 2006; 26(4): 1373 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jimenez-Perianez, G. Ojeda, G. Criado, A. Sanchez, E. Pini, J. Madrenas, J. M. Rojo, and P. Portoles Complement regulatory protein Crry/p65-mediated signaling in T lymphocytes: role of its cytoplasmic domain and partitioning into lipid rafts J. Leukoc. Biol., December 1, 2005; 78(6): 1386 - 1396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Chen, M. Takeda, and R. A. Lamb Influenza Virus Hemagglutinin (H3 Subtype) Requires Palmitoylation of Its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in Their Ability To Support Assembly J. Virol., November 1, 2005; 79(21): 13673 - 13684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Martin, D. M. Roth, D. A. Jans, C. W. Pouton, L. J. Partridge, P. N. Monk, and G. W. Moseley Tetraspanins in Viral Infections: a Fundamental Role in Viral Biology? J. Virol., September 1, 2005; 79(17): 10839 - 10851. [Full Text] [PDF]
|
|
|
|
|
|
Q.-R. Liu, T. Drgon, D. Walther, C. Johnson, O. Poleskaya, J. Hess, and G. R. Uhl Pooled association genome scanning: Validation and use to identify addiction vulnerability loci in two samples PNAS, August 16, 2005; 102(33): 11864 - 11869. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Levy and T. Shoham Protein-Protein Interactions in the Tetraspanin Web Physiology, August 1, 2005; 20(4): 218 - 224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Stein, P. Primakoff, and D. Myles Sperm-egg fusion: events at the plasma membrane J. Cell Sci., December 15, 2004; 117(26): 6269 - 6274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Schuck and K. Simons Polarized sorting in epithelial cells: raft clustering and the biogenesis of the apical membrane J. Cell Sci., December 1, 2004; 117(25): 5955 - 5964. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
