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J. Biol. Chem., Vol. 279, Issue 33, 34373-34379, August 13, 2004

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Nitric Oxide Inhibits Glucocorticoid-induced Apoptosis of Thymocytes by Repressing the SRG3 Expression^*

Seung M. Jeong, Kyoo Y. Lee, Dongho Shin, Heekyoung Chung¶, Sung H. Jeon||, and Rho H. Seong||

From the School of Biological Sciences and Institute of Molecular Biology & Genetics, Seoul National University, Seoul 151-742, Korea and the ^¶Department of Pathology, Hanyang, University School of Medicine, Seoul 133-791, Korea

Nitric oxide (NO) plays many roles in the immune system. It has been known that NO rescues thymocytes from glucocorticoid (GC)-induced apoptosis. However, the downstream target of NO in the protection from GC-induced thymocyte apoptosis has yet to be identified. We previously reported that GC sensitivity of developing thymocytes is dependent on the expression level of SRG3. In the present report, we found that NO repressed the SRG3 expression in both primary thymocytes and 16610D9 thymoma cells. Specifically, NO down-regulated the transcription of SRG3 via the inactivation of the transcription factor Sp1 DNA-binding activity to the SRG3 promoter. In addition, overexpression of SRG3 by a heterologous promoter reduced NO-mediated rescue of thymocytes from GC-induced apoptosis. These observations strongly suggest that NO may be involved in protecting immature thymocytes from GC-induced apoptosis by repressing the SRG3 expression in thymus.

Received for publication, March 29, 2004 , and in revised form, June 2, 2004.

^* This work was supported in part by a grant from Korea Research Foundation (Grant KRF-2002-042-C00064). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Supported by the BK21 Program from the Ministry of Education & Human Resources Development.

^|| To whom correspondence should be addressed. Tel.: 82-2-880-7567; Fax: 82-2-887-9984; E-mail: rhseong{at}plaza.snu.ac.kr (R. H. S.) or jeonsho{at}snu.ac.kr (S. H. J.).

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