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J. Biol. Chem., Vol. 279, Issue 38, 39783-39788, September 17, 2004

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Abscisic Acid Signaling through Cyclic ADP-ribose in Hydroid Regeneration^*

Stefania Puce, Giovanna Basile, Giorgio Bavestrello, Santina Bruzzone, Carlo Cerrano¶, Marco Giovine||, Attilio Arillo¶, and Elena Zocchi**

From the Dipartimento di Scienze del Mare, Università Politecnica delle Marche, Via Brecce Bianche, 60131 Ancona, Italy, Dipartimento di Medicina Sperimentale, Sezione Biochimica and Center of Excellence for Biomedical Research, Università di Genova, Viale Benedetto XV n°1, 16132 Genova, Italy, ^¶Dipartimento per lo Studio del Territorio e delle sue Risorse, Università di Genova, Corso Europa 26, 16132 Genova, Italy, and ^||Consiglio Nazionale delle Ricerche, Direzione Progetto Finalizzato Biotecnologie, Via L. Alberti 4, 16132 Genova, Italy

Cyclic ADP-ribose (cADPR) is an intracellular calcium (Ca²⁺_i) mobilizer involved in fundamental cell functions from protists to higher plants and mammals. Biochemical similarities between the drought-signaling cascade in plants and the temperature-sensing pathway in marine sponges suggest an ancient evolutionary origin of a signaling cascade involving the phytohormone abscisic acid (ABA), cADPR, and Ca²⁺_i. In Eudendrium racemosum (Hydrozoa, Cnidaria), exogenously added ABA stimulated ADP-ribosyl cyclase activity via a protein kinase A (PKA)-mediated phosphorylation and increased regeneration in the dark to levels observed under light conditions. Light stimulated endogenous ABA synthesis, which was conversely inhibited by the inhibitor of plant ABA synthesis Fluridone. The signal cascade of light-induced regeneration uncovered in E. racemosum: light ABA PKA cyclase activation [cADPR]_i [Ca²⁺]_i regeneration is the first report of a complete signaling pathway in Eumetazoa involving a phytohormone.

Received for publication, May 13, 2004 , and in revised form, June 29, 2004.

^* This work has been supported by grants from the Italian Ministry of Education, University and Scientific Research, Associazione Italiana per la Ricerca sul Cancro (AIRC), University of Genova, Consiglio Nazionale delle Richerce (CNR) (Target Project on Biotechnology), Consorzio Interuniversitario sulle Biotecnologie (CIB), and Fondazione Cassa di Risparmio di Genova e Imperia (CARIGE, Stem Cell Project). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^** To whom correspondence should be addressed: Dipartmento di Medicina Sperimentale-Sezione Biochimica, Viale Benedetto XV n°1, 16132 Genova, Italy. Tel.: 39-010-3538151; Fax: 39-010-354415; E-mail: ezocchi{at}unige.it.

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