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J. Biol. Chem., Vol. 279, Issue 42, 43363-43366, October 15, 2004

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Minireview

Intranuclear Trafficking: Organization and Assembly of Regulatory Machinery for Combinatorial Biological Control^*

Sayyed K. Zaidi, Daniel W. Young, Je-Yong Choi, Jitesh Pratap, Amjad Javed, Martin Montecino¶, Janet L. Stein, Jane B. Lian, Andre J. van Wijnen, and Gary S. Stein||

From the Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, ^¶Departamento de Biologica Molecular, Universidad de Concepcion, Concepcion 407-9100, Chile, and Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Korea

The molecular logistics of nuclear regulatory processes necessitate temporal and spatial regulation of protein-protein and protein-DNA interactions in response to physiological cues. Biochemical, in situ, and in vivo genetic evidence demonstrates the requirement for intranuclear localization of regulatory complexes that functionally couple cellular responses to signals that mediate combinatorial control of gene expression. We have summarized evidence that subnuclear targeting of transcription factors mechanistically links gene expression with architectural organization and assembly of nuclear regulatory machinery for biological control. The compromised intranuclear targeting of regulatory proteins under pathological conditions provides options for the diagnosis and treatment of disease.

^* This minireview will be reprinted in the 2004 Minireview Compendium, which will be available in January, 2005. Studies from our laboratory presented in this review were supported in part by National Institutes of Health Grants PO1 AR48818, PO1 CA82834, and 5 P30 DK32520.

^|| To whom correspondence should be addressed: Dept. of Cell Biology, University of Massachusetts Medical School, 55 Lake Ave. North, Worcester, MA 01655. Tel.: 508-856-5625; Fax: 508-856-6800; E-mail: gary.stein{at}umassmed.edu.

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