JBC Focus on PI3-Kinase with Echelon

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M409962200 on September 9, 2004

J. Biol. Chem., Vol. 279, Issue 47, 49082-49090, November 19, 2004
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
279/47/49082    most recent
M409962200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dufner-Beattie, J.
Right arrow Articles by Andrews, G. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dufner-Beattie, J.
Right arrow Articles by Andrews, G. K.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

The Adaptive Response to Dietary Zinc in Mice Involves the Differential Cellular Localization and Zinc Regulation of the Zinc Transporters ZIP4 and ZIP5*

Jodi Dufner-Beattie{ddagger}, Yien-Ming Kuo§, Jane Gitschier§, and Glen K. Andrews{ddagger}

From the {ddagger}Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Kansas 66160-7421 and §Howard Hughes Medical Institute and Departments of Medicine and Pediatrics, University of California, San Francisco, California 94143

The ZIP5 gene encodes a protein closely related to ZIP4, a zinc transporter mutated in the human genetic disorder acrodermatitis enteropathica. Herein, we demonstrate that mouse ZIP5 and ZIP4 genes are co-expressed in several tissues involved in zinc homeostasis (intestine, pancreas, embryonic yolk sac). However, unlike expression of the ZIP4 gene, which is induced during periods of zinc deficiency, ZIP5 gene expression is unaltered by dietary zinc. Immunohistochemistry localizes ZIP5 to the basolateral surfaces of enterocytes, acinar cells, and visceral endoderm cells in mice fed a zinc-adequate diet. However, this protein is removed from these cell surfaces and internalized during dietary zinc deficiency. In contrast, ZIP4 is induced and recruited to the apical surface of enterocytes and endoderm cells during zinc deficiency. In the pancreas, ZIP4 is expressed in {beta}-cells, whereas ZIP5 is expressed in acinar cells. These results suggest that the function of ZIP5 is antagonistic to that of ZIP4 in the control of zinc homeostasis; rather than functioning in the acquisition of dietary zinc, as does ZIP4, ZIP5 may function in the removal of zinc from the body. Thus, during periods when dietary zinc is replete, ZIP5 may function to remove zinc from the blood via the pancreas and intestine, the major sites of zinc excretion in mammals, whereas the acquisition of dietary zinc by intestinal ZIP4 would be minimal. In contrast, during periods of dietary zinc deficiency when secretion of zinc by the pancreas and intestine is minimized, ZIP5 is removed from the cell surface, and the intestinal uptake of zinc is augmented by induction of ZIP4.

Received for publication, August 30, 2004

* This work was funded in part by National Institutes of Health Grants DK063975 and DK50181 (to G. K. A.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed: Dept. of Biochemistry and Molecular Biology, Mail Stop 3030, University of Kansas Medical Center, 39th and Rainbow Blvd., Kansas City, KS 66160-7421. Tel.: 913-588-6935; Fax: 913-588-2711; E-mail: gandrews{at}kumc.edu.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 EndocrinologyHome page
K. M. Taylor, P. Vichova, N. Jordan, S. Hiscox, R. Hendley, and R. I. Nicholson
ZIP7-Mediated Intracellular Zinc Transport Contributes to Aberrant Growth Factor Signaling in Antihormone-Resistant Breast Cancer Cells
Endocrinology, October 1, 2008; 149(10): 4912 - 4920.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. Girijashanker, L. He, M. Soleimani, J. M. Reed, H. Li, Z. Liu, B. Wang, T. P. Dalton, and D. W. Nebert
Slc39a14 Gene Encodes ZIP14, A Metal/Bicarbonate Symporter: Similarities to the ZIP8 Transporter
Mol. Pharmacol., May 1, 2008; 73(5): 1413 - 1423.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. Kambe, J. Geiser, B. Lahner, D. E. Salt, and G. K. Andrews
Slc39a1 to 3 (subfamily II) Zip genes in mice have unique cell-specific functions during adaptation to zinc deficiency
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1474 - R1481.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. V. Gyulkhandanyan, H. Lu, S. C. Lee, A. Bhattacharjee, N. Wijesekara, J. E. M. Fox, P. E. MacDonald, F. Chimienti, F. F. Dai, and M. B. Wheeler
Investigation of Transport Mechanisms and Regulation of Intracellular Zn2+ in Pancreatic {alpha}-Cells
J. Biol. Chem., April 11, 2008; 283(15): 10184 - 10197.
[Abstract] [Full Text] [PDF]

Home page
 Eukaryot CellHome page
S. J. Dainty, C. A. Kennedy, S. Watt, J. Bahler, and S. K. Whitehall
Response of Schizosaccharomyces pombe to Zinc Deficiency
Eukaryot. Cell, March 1, 2008; 7(3): 454 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Zimnicka, E. B. Maryon, and J. H. Kaplan
Human Copper Transporter hCTR1 Mediates Basolateral Uptake of Copper into Enterocytes: IMPLICATIONS FOR COPPER HOMEOSTASIS
J. Biol. Chem., September 7, 2007; 282(36): 26471 - 26480.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
J. Dufner-Beattie, B. P. Weaver, J. Geiser, M. Bilgen, M. Larson, W. Xu, and G. K. Andrews
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency
Hum. Mol. Genet., June 15, 2007; 16(12): 1391 - 1399.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
J. A. Jamieson, J. N. Shuhyta, and C. G. Taylor
Lead Does Not Affect Transcription of Intestinal Zinc-Binding Proteins in Growing Rats
Experimental Biology and Medicine, June 1, 2007; 232(6): 744 - 753.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Mao, B.-E. Kim, F. Wang, D. J. Eide, and M. J. Petris
A Histidine-rich Cluster Mediates the Ubiquitination and Degradation of the Human Zinc Transporter, hZIP4, and Protects against Zinc Cytotoxicity
J. Biol. Chem., March 9, 2007; 282(10): 6992 - 7000.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
J. P Bressler, L. Olivi, J. H. Cheong, Y. Kim, A. Maerten, and D. Bannon
Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities
Human and Experimental Toxicology, March 1, 2007; 26(3): 221 - 229.
[Abstract] [PDF]

Home page
 J. Histochem. Cytochem.Home page
Y. Y. Yu, C. P. Kirschke, and L. Huang
Immunohistochemical Analysis of ZnT1, 4, 5, 6, and 7 in the Mouse Gastrointestinal Tract
J. Histochem. Cytochem., March 1, 2007; 55(3): 223 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C. Lang, C. Murgia, M. Leong, L.-W. Tan, G. Perozzi, D. Knight, R. Ruffin, and P. Zalewski
Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation
Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L577 - L584.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. J. Cousins, J. P. Liuzzi, and L. A. Lichten
Mammalian Zinc Transport, Trafficking, and Signals
J. Biol. Chem., August 25, 2006; 281(34): 24085 - 24089.
[Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
L. He, K. Girijashanker, T. P. Dalton, J. Reed, H. Li, M. Soleimani, and D. W. Nebert
ZIP8, Member of the Solute-Carrier-39 (SLC39) Metal-Transporter Family: Characterization of Transporter Properties
Mol. Pharmacol., July 1, 2006; 70(1): 171 - 180.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. V. Gyulkhandanyan, S. C. Lee, G. Bikopoulos, F. Dai, and M. B. Wheeler
The Zn2+-transporting Pathways in Pancreatic beta-Cells: A ROLE FOR THE L-TYPE VOLTAGE-GATED Ca2+ CHANNEL
J. Biol. Chem., April 7, 2006; 281(14): 9361 - 9372.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. B. Aydemir, R. K. Blanchard, and R. J. Cousins
Zinc supplementation of young men alters metallothionein, zinc transporter, and cytokine gene expression in leukocyte populations
PNAS, February 7, 2006; 103(6): 1699 - 1704.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Dufner-Beattie, Z. L. Huang, J. Geiser, W. Xu, and G. K. Andrews
Generation and Characterization of Mice Lacking the Zinc Uptake Transporter ZIP3
Mol. Cell. Biol., July 1, 2005; 25(13): 5607 - 5615.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. L. Kelleher and B. Lonnerdal
Zip3 plays a major role in zinc uptake into mammary epithelial cells and is regulated by prolactin
Am J Physiol Cell Physiol, May 1, 2005; 288(5): C1042 - C1047.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Huang, C. P. Kirschke, Y. Zhang, and Y. Y. Yu
The ZIP7 Gene (Slc39a7) Encodes a Zinc Transporter Involved in Zinc Homeostasis of the Golgi Apparatus
J. Biol. Chem., April 15, 2005; 280(15): 15456 - 15463.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2004 by the American Society for Biochemistry and Molecular Biology.