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J. Biol. Chem., Vol. 279, Issue 47, 49455-49459, November 19, 2004

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The Soh1/MED31 Protein Is an Ancient Component of Schizosaccharomyces pombe and Saccharomyces cerevisiae Mediator^*

Tomas Linder and Claes M. Gustafsson

From the Department of Medical Nutrition, Karolinska Institute, Novum, Karolinska University Hospital, SE-141 86 Stockholm, Sweden

We here demonstrated that the Soh1/MED31 protein is a stable component of Mediator complex isolated from Schizosaccharomyces pombe and Saccharomyces cerevisiae. Bioinformatic analysis traces the Soh1/MED31 family of Mediator subunits to the point of major eukaryotic divergence, before the appearance of the canonical heptapeptide repeat structure of the RNA polymerase II C-terminal domain.

Received for publication, August 6, 2004 , and in revised form, August 31, 2004.

^* This work was supported by grants (to C. M. G.) from the Swedish Research Council, the Swedish Cancer Society, and the Swedish Foundation for Strategic Research. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Tel.: 46-8-58583974; Fax: 46-8-7116659; E-mail: claes.gustafsson{at}mednut.ki.se.

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