HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 279, Issue 51, 53222-53231, December 17, 2004

This Article Full Text Full Text (PDF) All Versions of this Article: 279/51/53222    most recent M410539200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Munroe, M. E. Articles by Bishop, G. A. Search for Related Content PubMed PubMed Citation Articles by Munroe, M. E. Articles by Bishop, G. A. Social Bookmarking                      What's this?

Role of Tumor Necrosis Factor (TNF) Receptor-associated Factor 2 (TRAF2) in Distinct and Overlapping CD40 and TNF Receptor 2/CD120b-mediated B Lymphocyte Activation^*

Melissa E. Munroe and Gail A. Bishop¶||

From the Departments of Microbiology and Internal Medicine, The University of Iowa and ^¶Veterans Affairs Medical Center, Iowa City, Iowa 52242

Members of the tumor necrosis factor receptor (TNFR) family play a variety of roles in the regulation of lymphocyte activation. An important TNFR family member for B cell activation is CD40. CD40 signals stimulate B cell TNF- secretion, which subsequently signals via TNFR2 (CD120b) to enhance B cell activation. Although the function of the pro-apoptotic and pro-inflammatory receptor TNFR1 (CD120a) has been the subject of much research, less is understood about the distinct contributions of CD120b to cell activation and how it stimulates downstream events. Members of the tumor necrosis factor receptor family bind various members of the cytoplasmic adapter protein family, the tumor necrosis factor receptor-associated factors (TRAFs), during signaling. Both CD40 and CD120b bind TNF receptor-associated factor 2 (TRAF2) upon ligand stimulation. Wild type and TRAF2-deficient B cells expressing CD40 or the hybrid molecule (human) CD40 (mouse)-CD120b were examined. CD40- and CD120b-mediated IgM secretion were partly TRAF2-dependent, but only CD40 required TRAF2 for c-Jun N-terminal kinase activation. CD40 and CD120b used primarily divergent mechanisms to activate NF-B, exemplifying how TNFR family members can use diverse mechanisms to mediate similar downstream events.

Received for publication, September 13, 2004

^* This work was supported by NIH Grants AI28847, AI49993, and CA099997 and a VA Career Award (to G. A. B.) and by NIH Training Grants AI07343 and AI07260 (to M. E. M.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^|| To whom correspondence should be addressed: 2193B MERF, Dept. of Microbiology, University of Iowa, Iowa City, IA 52242. Tel.: 319-335-7945; Fax: 319-335-9006; E-mail: gail-bishop{at}uiowa.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. Baumel, A. Lechner, T. Hehlgans, and D. N. Mannel Enhanced susceptibility to Con A-induced liver injury in mice transgenic for the intracellular isoform of human TNF receptor type 2 J. Leukoc. Biol., July 1, 2008; 84(1): 162 - 169. [Abstract] [Full Text] [PDF]

				R. M. Rahhal, T. J. Vanden Bush, M. K. McLendon, M. A. Apicella, and G. A. Bishop Differential effects of Francisella tularensis lipopolysaccharide on B lymphocytes J. Leukoc. Biol., October 1, 2007; 82(4): 813 - 820. [Abstract] [Full Text] [PDF]

				M. E. Munroe, J. L. Arbiser, and G. A. Bishop Honokiol, a Natural Plant Product, Inhibits Inflammatory Signals and Alleviates Inflammatory Arthritis J. Immunol., July 15, 2007; 179(2): 753 - 763. [Abstract] [Full Text] [PDF]

				L.-F. Lu, C. L. Ahonen, E. F. Lind, V. S. Raman, W. J. Cook, L.-L. Lin, and R. J. Noelle The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation Blood, July 1, 2007; 110(1): 193 - 200. [Abstract] [Full Text] [PDF]

				M. E. Munroe and G. A. Bishop A Costimulatory Function for T Cell CD40 J. Immunol., January 15, 2007; 178(2): 671 - 682. [Abstract] [Full Text] [PDF]

				P. Xie, B. S. Hostager, M. E. Munroe, C. R. Moore, and G. A. Bishop Cooperation between TNF Receptor-Associated Factors 1 and 2 in CD40 Signaling J. Immunol., May 1, 2006; 176(9): 5388 - 5400. [Abstract] [Full Text] [PDF]

				R. M. Andrade, M. Wessendarp, J.-A. C. Portillo, J.-Q. Yang, F. J. Gomez, J. E. Durbin, G. A. Bishop, and C. S. Subauste TNF Receptor-Associated Factor 6-Dependent CD40 Signaling Primes Macrophages to Acquire Antimicrobial Activity in Response to TNF-{alpha} J. Immunol., November 1, 2005; 175(9): 6014 - 6021. [Abstract] [Full Text] [PDF]

				C. H. Yang, A. Murti, and L. M. Pfeffer Interferon Induces NF-{kappa}B-inducing Kinase/Tumor Necrosis Factor Receptor-associated Factor-dependent NF-{kappa}B Activation to Promote Cell Survival J. Biol. Chem., September 9, 2005; 280(36): 31530 - 31536. [Abstract] [Full Text] [PDF]