Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M413949200 on December 28, 2004

J. Biol. Chem., Vol. 280, Issue 10, 8651-8659, March 11, 2005
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
280/10/8651    most recent
M413949200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ramakrishnan, S. N.
Right arrow Articles by Muscat, G. E. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ramakrishnan, S. N.
Right arrow Articles by Muscat, G. E. O.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Rev-erb{beta} Regulates the Expression of Genes Involved in Lipid Absorption in Skeletal Muscle Cells

EVIDENCE FOR CROSS-TALK BETWEEN ORPHAN NUCLEAR RECEPTORS AND MYOKINES*

Sathiya N. Ramakrishnan, Patrick Lau, Les J. Burke, and George E. O. Muscat{ddagger}

From the Institute for Molecular Bioscience, Division of Molecular Genetics and Development, University of Queensland, St. Lucia, Queensland 4072, Australia

Rev-erb{beta} is an orphan nuclear receptor that selectively blocks trans-activation mediated by the retinoic acid-related orphan receptor-{alpha} (ROR{alpha}). ROR{alpha} has been implicated in the regulation of high density lipoprotein cholesterol, lipid homeostasis, and inflammation. Reverb{beta} and ROR{alpha} are expressed in similar tissues, including skeletal muscle; however, the pathophysiological function of Rev-erb{beta} has remained obscure. We hypothesize from the similar expression patterns, target genes, and overlapping cognate sequences of these nuclear receptors that Rev-erb{beta} regulates lipid metabolism in skeletal muscle. This lean tissue accounts for >30% of total body weight and 50% of energy expenditure. Moreover, this metabolically demanding tissue is a primary site of glucose disposal, fatty acid oxidation, and cholesterol efflux. Consequently, muscle has a significant role in insulin sensitivity, obesity, and the blood-lipid profile. We utilize ectopic expression in skeletal muscle cells to understand the regulatory role of Rev-erb{beta} in this major mass peripheral tissue. Exogenous expression of a dominant negative version of mouse Rev-erb{beta} decreases the expression of many genes involved in fatty acid/lipid absorption (including Cd36, and Fabp-3 and -4). Interestingly, we observed a robust induction (>15-fold) in mRNA expression of interleukin-6, an "exercise-induced myokine" that regulates energy expenditure and inflammation. Furthermore, we observed the dramatic repression (>20-fold) of myostatin mRNA, another myokine that is a negative regulator of muscle hypertrophy and hyperplasia that impacts on body fat accumulation. This study implicates Rev-erb{beta} in the control of lipid and energy homoeostasis in skeletal muscle. In conclusion, we speculate that selective modulators of Rev-erb{beta} may have therapeutic utility in the treatment of dyslipidemia and regulation of muscle growth.

Received for publication, December 13, 2004 , and in revised form, December 20, 2004.

* This work was supported by a National Health and Medical Research Council of Australia (NHMRC) project grant. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

{ddagger} Principal Research Fellow of the NHMRC. To whom correspondence should be addressed. Tel.: 61-7-3346-2039; E-mail: g.muscat{at}imb.uq.edu.au.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
S. Hummasti and P. Tontonoz
Adopting New Orphans into the Family of Metabolic Regulators
Mol. Endocrinol., August 1, 2008; 22(8): 1743 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
T. P. Burris
Nuclear Hormone Receptors for Heme: REV-ERB{alpha} and REV-ERB{beta} Are Ligand-Regulated Components of the Mammalian Clock
Mol. Endocrinol., July 1, 2008; 22(7): 1509 - 1520.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes and Vascular Disease ResearchHome page
H. Duez and B. Staels
The nuclear receptors Rev-erbs and RORs integrate circadian rhythms and metabolism
Diabetes and Vascular Disease Research, June 1, 2008; 5(2): 82 - 88.
[Abstract] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Watarai, E. Sekine, S. Inoue, R. Nakagawa, T. Kaisho, and M. Taniguchi
PDC-TREM, a plasmacytoid dendritic cell-specific receptor, is responsible for augmented production of type I interferon
PNAS, February 26, 2008; 105(8): 2993 - 2998.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J. J. McCarthy, J. L. Andrews, E. L. McDearmon, K. S. Campbell, B. K. Barber, B. H. Miller, J. R. Walker, J. B. Hogenesch, J. S. Takahashi, and K. A. Esser
Identification of the circadian transcriptome in adult mouse skeletal muscle
Physiol Genomics, September 11, 2007; 31(1): 86 - 95.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
S. Raichur, P. Lau, B. Staels, and G. E O Muscat
Retinoid-related orphan receptor {gamma} regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production
J. Mol. Endocrinol., July 1, 2007; 39(1): 29 - 44.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. A. Pearen, J. G. Ryall, M. A. Maxwell, N. Ohkura, G. S. Lynch, and G. E. O. Muscat
The Orphan Nuclear Receptor, NOR-1, Is a Target of {beta}-Adrenergic Signaling in Skeletal Muscle
Endocrinology, November 1, 2006; 147(11): 5217 - 5227.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
J.-J. Park, J. R. Berggren, M. W. Hulver, J. A Houmard, and E. P. Hoffman
GRB14, GPD1, and GDF8 as potential network collaborators in weight loss-induced improvements in insulin action in human skeletal muscle
Physiol Genomics, October 11, 2006; 27(2): 114 - 121.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. A. Myers, S.-C. M. Wang, and G. E. O. Muscat
The Chicken Ovalbumin Upstream Promoter-Transcription Factors Modulate Genes and Pathways Involved in Skeletal Muscle Cell Metabolism
J. Biol. Chem., August 25, 2006; 281(34): 24149 - 24160.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. G. Smith and G. E. O. Muscat
Orphan nuclear receptors: therapeutic opportunities in skeletal muscle
Am J Physiol Cell Physiol, August 1, 2006; 291(2): C203 - C217.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Maxwell, M. E. Cleasby, A. Harding, A. Stark, G. J. Cooney, and G. E. O. Muscat
Nur77 Regulates Lipolysis in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN THE {beta}-ADRENERGIC AND AN ORPHAN NUCLEAR HORMONE RECEPTOR PATHWAY
J. Biol. Chem., April 1, 2005; 280(13): 12573 - 12584.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement