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J. Biol. Chem., Vol. 280, Issue 18, 17938-17944, May 6, 2005

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Adenoviral Gene Transfer of the NF-B Inhibitory Protein ABIN-1 Decreases Allergic Airway Inflammation in a Murine Asthma Model^*

Karim El Bakkouri, Andy Wullaert, Mira Haegman, Karen Heyninck, and Rudi Beyaert¶

From the Unit of Molecular Signal Transduction in Inflammation, Department of Molecular Biomedical Research, Ghent University-VIB, B-9052 Ghent, Belgium

Airway inflammation is a characteristic of many lung disorders, including asthma and chronic obstructive pulmonary disease. Using a murine model of allergen-induced asthma, we have demonstrated that adenovirus-mediated delivery of the nuclear factor-B (NF-B) inhibitory protein ABIN-1 to the lung epithelium results in a considerable reduction of allergen-induced eosinophil infiltration into the lungs. This is associated with an ABIN-1-induced decrease in allergen-specific immunoglobulin E levels in serum, as well as a significant reduction of eotaxin, interleukin-4, and interleukin-1 in bronchoalveolar lavage fluid. These findings not only prove that NF-B plays a critical role in the pathogenesis of allergic inflammation but also illustrate that inhibiting NF-B could have therapeutic value in the treatment of asthma and potentially other chronic inflammatory lung diseases.

Received for publication, December 2, 2004 , and in revised form, January 25, 2005.

^* This work was supported in part by grants from the Fund for Scientific Research-Flanders (FWO-Vlaanderen), the Belgian Federation against Cancer, the Flemish Institute For the Promotion of Scientific-Technological Research in the Industry (IWT), and the Interuniversity Attraction Poles (IUAP-V). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Recipient of a research fellowship from the IWT.

A postdoctoral researcher with the FWO-Vlaanderen.

^¶ To whom correspondence should be addressed: Unit of Molecular Signal Transduction in Inflammation, Dept. of Molecular Biomedical Research, Ghent University - VIB, Technologiepark 927, B-9052 Ghent, Belgium. Tel.: 32-9-3313770; Fax: 32-9-3313609; E-mail: rudi.beyaert{at}dmbr.UGent.be.

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