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J. Biol. Chem., Vol. 280, Issue 18, 18163-18170, May 6, 2005

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Genetic- or Transforming Growth Factor-1-induced Changes in Epidermal Peroxisome Proliferator-activated Receptor / Expression Dictate Wound Repair Kinetics^*

Nguan Soon Tan, Liliane Michalik, Béatrice Desvergne, and Walter Wahli

From the Center for Integrative Genomics, National Center of Competence in Research Frontiers in Genetics, University of Lausanne, Lausanne CH-1015, Switzerland

Advances in wound care are of great importance in clinical injury management. In this respect, the nuclear receptor peroxisome proliferator-activated receptor (PPAR)/ occupies a unique position at the intersection of diverse inflammatory or anti-inflammatory signals that influence wound repair. This study shows how changes in PPAR/ expression have a profound effect on wound healing. Using two different in vivo models based on topical application of recombinant transforming growth factor (TGF)-1 and ablation of the Smad3 gene, we show that prolonged expression and activity of PPAR/ accelerate wound closure. The results reveal a dual role of TGF-1 as a chemoattractant of inflammatory cells and repressor of inflammation-induced PPAR/ expression. Also, they provide insight into the so far reported paradoxical effects of the application of exogenous TGF-1 at wound sites.

Received for publication, November 12, 2004 , and in revised form, January 18, 2005.

^* This work was supported by grants from the Swiss National Science Foundation (to W. W. and B. D.) and the Etat de Vaud. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The on-line version of this article (available at http://www.jbc.org) contains Figs. S1–S6.

To whom correspondence should be addressed. Tel.: 41-21-692-4110; Fax: 41-21-692-4115; E-mail: walter.wahli{at}unil.ch.

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