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J. Biol. Chem., Vol. 280, Issue 2, 1149-1155, January 14, 2005

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The ETS Domain Transcription Factor Elk-1 Regulates the Expression of Its Partner Protein, SRF^*

Aneta Kasza, Amanda O'Donnell, Karen Gascoigne, Leo A. H. Zeef, Andy Hayes, and Andrew D. Sharrocks

From the Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, United Kingdom

The ternary complex factors (TCF) are a subfamily of ETS domain transcription factors that bind and activate serum response elements (SREs) in the promoters of target genes in a ternary complex with a second transcription factor, serum response factor (SRF). Here, we have identified the SRF gene as a target for the TCFs, thereby providing a positive feedback loop whereby TCF activation leads to the enhancement of the expression of its partner protein SRF. The binding of the TCF Elk-1 to the SRF promoter and subsequent regulation of SRF expression occurs in a ternary complex-dependent manner. Our data therefore reveal that SRF is an important target for the ERK and Rho signaling pathways that converge on a ternary TCF-SRF complex at the SRE on the SRF promoter.

Received for publication, September 29, 2004 , and in revised form, November 3, 2004.

^* This work was supported in part by grants from the Wellcome Trust and the Association for International Cancer Research (AICR). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Supported by Research Fellowships from the Wellcome Trust and the Foundation for Polish Science.

To whom correspondence should be addressed. Tel.: 44-161-275-5979: Fax: 44-161-275-5082; E-mail: a.d.sharrocks{at}man.ac.uk.

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