Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M414328200 on June 13, 2005 Originally published In Press as doi:10.1074/jbc.M414328200 on June 13, 2005 Originally published In Press as doi:10.1074/jbc.M414328200 on June 9, 2005 Originally published In Press as doi:10.1074/jbc.M414328200 on June 6, 2005

J. Biol. Chem., Vol. 280, Issue 31, 28476-28483, August 5, 2005
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
280/31/28476    most recent
M414328200v4
M414328200v3
M414328200v2
M414328200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Côté, J.
Right arrow Articles by Richard, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Côté, J.
Right arrow Articles by Richard, S.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Tudor Domains Bind Symmetrical Dimethylated Arginines*

Jocelyn Côté{ddagger} and Stéphane Richard, Investigator of the CIHR§

From the Terry Fox Molecular Oncology Group and the Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis Jewish General Hospital and Departments of Oncology and Medicine, McGill University, Montréal, Québec H3T 1E2, Canada

The Tudor domain is an ~60-amino acid structure motif in search of a function. Herein we show that the Tudor domains of the spinal muscular atrophy gene product SMN, the splicing factor 30 kDa (SPF30), and the Tudor domain-containing 3 (TDRD3) proteins interacted with arginine-glycine-rich motifs in a methylarginine-dependent manner. The Tudor domains also associated with methylarginine-containing cellular proteins, providing evidence that methylated arginines represent physiological ligands for this protein module. In addition, we report that spliceosomal small nuclear ribonucleoprotein particles core Sm proteins accumulated in the cytoplasm when arginine methylation was inhibited with adenosine dialdehyde or in the presence of an excessive amount of unmethylated arginine-glycine-rich peptides. These data provide in vivo evidence in support of a role for arginine methylation in the proper assembly and localization of spliceosomal Sm proteins.

Received for publication, December 20, 2004 , and in revised form, May 31, 2005.

* This work was supported by Grant MOP-67070 from the Canadian Institutes of Health Research (CIHR) (to S. R.) and a research grant from the Families of Spinal Muscular Atrophy (to J. C.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

{ddagger} New Investigator of the CIHR. Present address: Dept. of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.

§ To whom correspondence should be addressed: Lady Davis Inst., 3755 Côte-Ste-Catherine Rd., Montréal, Québec, Canada H3T 1E2. Tel.: 514-340-8260; Fax: 514-340-8295; E-mail: stephane.richard{at}mcgill.ca.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
Y.-H. Lee and M. R. Stallcup
Minireview: Protein Arginine Methylation of Nonhistone Proteins in Transcriptional Regulation
Mol. Endocrinol., April 1, 2009; 23(4): 425 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
S. B. Patel and M. Bellini
The assembly of a spliceosomal small nuclear ribonucleoprotein particle
Nucleic Acids Res., November 1, 2008; 36(20): 6482 - 6493.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
B. Linder, O. Plottner, M. Kroiss, E. Hartmann, B. Laggerbauer, G. Meister, E. Keidel, and U. Fischer
Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP
Hum. Mol. Genet., October 15, 2008; 17(20): 3236 - 3246.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
I. Goulet, S. Boisvenue, S. Mokas, R. Mazroui, and J. Cote
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules
Hum. Mol. Genet., October 1, 2008; 17(19): 3055 - 3074.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
C.-L. Li, W.-Z. Yang, Y.-P. Chen, and H. S. Yuan
Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing
Nucleic Acids Res., June 1, 2008; 36(11): 3579 - 3589.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. T. Little and M. S. Jurica
Splicing Factor SPF30 Bridges an Interaction between the Prespliceosome Protein U2AF35 and Tri-small Nuclear Ribonucleoprotein Protein hPrp3
J. Biol. Chem., March 28, 2008; 283(13): 8145 - 8152.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
H. Tadesse, J. Deschenes-Furry, S. Boisvenue, and J. Cote
KH-type splicing regulatory protein interacts with survival motor neuron protein and is misregulated in spinal muscular atrophy
Hum. Mol. Genet., February 14, 2008; 17(4): 506 - 524.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
M. T. Bedford
Arginine methylation at a glance
J. Cell Sci., December 15, 2007; 120(24): 4243 - 4246.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
C. E. Beattie, T. L. Carrel, and M. L. McWhorter
Fishing for a Mechanism: Using Zebrafish to Understand Spinal Muscular Atrophy
J Child Neurol, August 1, 2007; 22(8): 995 - 1003.
[Abstract] [PDF]

Home page
 Nucleic Acids ResHome page
J. Yang, T. Valineva, J. Hong, T. Bu, Z. Yao, O. N. Jensen, M. J. Frilander, and O. Silvennoinen
Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome
Nucleic Acids Res., July 26, 2007; 35(13): 4485 - 4494.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Perreault, C. Lemieux, and F. Bachand
Regulation of the Nuclear Poly(A)-binding Protein by Arginine Methylation in Fission Yeast
J. Biol. Chem., March 9, 2007; 282(10): 7552 - 7562.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Bensing, S. O. Fetissov, J. Mulder, J. Perheentupa, J. Gustafsson, E. S. Husebye, M. Oscarson, O. Ekwall, P. A. Crock, T. Hokfelt, et al.
Pituitary autoantibodies in autoimmune polyendocrine syndrome type 1
PNAS, January 16, 2007; 104(3): 949 - 954.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. Anne, R. Ollo, A. Ephrussi, and B. M. Mechler
Arginine methyltransferase Capsuleen is essential for methylation of spliceosomal Sm proteins and germ cell formation in Drosophila
Development, January 1, 2007; 134(1): 137 - 146.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Zhang, J. Du, B. Sun, X. Dong, G. Xu, J. Zhou, Q. Huang, Q. Liu, Q. Hao, and J. Ding
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3
Nucleic Acids Res., December 2, 2006; 34(22): 6621 - 6628.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
T. L. Carrel, M. L. McWhorter, E. Workman, H. Zhang, E. C. Wolstencroft, C. Lorson, G. J. Bassell, A. H. M. Burghes, and C. E. Beattie
Survival Motor Neuron Function in Motor Axons Is Independent of Functions Required for Small Nuclear Ribonucleoprotein Biogenesis
J. Neurosci., October 25, 2006; 26(43): 11014 - 11022.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
A. L. Arkov, J.-Y. S. Wang, A. Ramos, and R. Lehmann
The role of Tudor domains in germline development and polar granule architecture
Development, October 15, 2006; 133(20): 4053 - 4062.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
B. Renvoise, K. Khoobarry, M.-C. Gendron, C. Cibert, L. Viollet, and S. Lefebvre
Distinct domains of the spinal muscular atrophy protein SMN are required for targeting to Cajal bodies in mammalian cells
J. Cell Sci., February 15, 2006; 119(4): 680 - 692.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2005 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement