| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 280, Issue 35, 31003-31010, September 2, 2005
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
¶
From the
Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599
Rho GTPases regulate multiple cellular processes including actin cytoskeletal rearrangements, transcriptional regulation, and oxidant production. The studies described herein demonstrate that small molecule redox agents, in addition to protein regulatory factors, can regulate the activity of redox-active Rho GTPases. A novel (GXXXXGK(S/T)C) motif, conserved in a number of Rho GTPases, appears critical for redox-mediated guanine nucleotide dissociation in vitro. A detailed molecular mechanism for redox regulation of GXXXXGK(S/T)C motif-containing Rho GTPases is proposed.
Received for publication, May 2, 2005 , and in revised form, June 6, 2005.
* This work was supported by National Institutes of Health Grants RO1CA89614-O1A1 and PO1 HL45100 (to S. L. C.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
¶ To whom correspondence should be addressed: Dept. of Biochemistry and Biophysics, University of North Carolina, 530 Mary Ellen Jones Bldg., Chapel Hill, NC 27599-7260. Tel.: 919-966-7139; Fax: 919-966-2852; E-mail: campbesl{at}med.unc.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Humar, H. Dohrmann, P. Stein, N. Andriopoulos, U. Goebel, M. Roesslein, R. Schmidt, C. I. Schwer, T. Loop, K. K. Geiger, et al. Thionamides Inhibit the Transcription Factor Nuclear Factor-{kappa}B by Suppression of Rac1 and Inhibitor of {kappa}B Kinase {alpha} J. Pharmacol. Exp. Ther., March 1, 2008; 324(3): 1037 - 1044. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Adachi, M. Yamamoto, and M. Suematsu Targeting NAD(P)H Oxidase: Ets-1 Regulates p47phox Circ. Res., November 9, 2007; 101(10): 962 - 964. [Full Text] [PDF]
|
|
|
|
 |
|
 K. W. Raines, M. G. Bonini, and S. L. Campbell Nitric oxide cell signaling: S-nitrosation of Ras superfamily GTPases Cardiovasc Res, July 15, 2007; 75(2): 229 - 239. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. McPhillips, W. J. Janssen, M. Ghosh, A. Byrne, S. Gardai, L. Remigio, D. L. Bratton, J. L. Kang, and P. Henson TNF-{alpha} Inhibits Macrophage Clearance of Apoptotic Cells via Cytosolic Phospholipase A2 and Oxidant-Dependent Mechanisms J. Immunol., June 15, 2007; 178(12): 8117 - 8126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Suarez, L. Gonzalez-Santiago, N. Zarich, A. Davalos, J. F. Aranda, M. A. Alonso, M. A. Lasuncion, J. M. Rojas, and A. Munoz Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content Mol. Pharmacol., November 1, 2006; 70(5): 1654 - 1663. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. N. Lyle and K. K. Griendling Modulation of vascular smooth muscle signaling by reactive oxygen species. Physiology, August 1, 2006; 21: 269 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Thakur, M. T. Pritchard, M. R. McMullen, Q. Wang, and L. E. Nagy Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells: role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-{alpha} production J. Leukoc. Biol., June 1, 2006; 79(6): 1348 - 1356. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
