HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 280, Issue 43, 35983-35991, October 28, 2005

This Article Full Text Full Text (PDF) All Versions of this Article: 280/43/35983    most recent M507339200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by D'Eon, T. M. Articles by Greenberg, A. S. Search for Related Content PubMed PubMed Citation Articles by D'Eon, T. M. Articles by Greenberg, A. S. Social Bookmarking                      What's this?

Estrogen Regulation of Adiposity and Fuel Partitioning

EVIDENCE OF GENOMIC AND NON-GENOMIC REGULATION OF LIPOGENIC AND OXIDATIVE PATHWAYS^*

Tara M. D'Eon1, Sandra C. Souza, Mark Aronovitz, Martin S. Obin, Susan K. Fried¶, and Andrew S. Greenberg2

From the Jean Mayer-United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, the Molecular Cardiology Research Institute, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, and the ^¶Division of Gerontology, Department of Medicine, University of Maryland School of Medicine, and Baltimore Veterans Affairs Medical Center, Baltimore, Maryland 21201

Menopause is associated with increased adiposity and greater risk of metabolic disease. In the ovariectomized (OVX) rodent model of menopause, increased adiposity is prevented by estrogen (E2) replacement, reflecting both anorexigenic and potentially metabolic actions of E2. To elucidate metabolic and molecular mechanisms by which E2 regulates fat storage and fat mobilization independently of reduced energy intake, C57 BL/6 mice were ovariectomized, randomized to estrogen (OVX-E2) or control pellet implants (OVX-C), and pairfed for 40 days. E2 treatment was associated with reduced adipose mass and adipocyte size and down-regulation of lipogenic genes in adipocytes under the control of sterol-regulatory element-binding protein 1c. Adipocytes of OVX-E2 mice contained >3-fold more perilipin protein than adipocytes of pairfed control (OVX) mice, and this difference was associated with enhanced ex vivo lipolytic response to catecholamines and with greater levels of serum-free fatty acids following fasting. As in adipose tissue, E2 decreased the expression of lipogenic genes in liver and skeletal muscle. In the latter, E2 appears to promote the partitioning of free fatty acids toward oxidation and away from triglyceride storage by up-regulating the expression of peroxisome proliferation activator receptor- and its downstream targets and also by directly and rapidly activating AMP-activated protein kinase. Thus, novel genomic and non-genomic actions of E2 promote leanness in OVX mice independently of reduced energy intake.

Received for publication, July 6, 2005 , and in revised form, August 8, 2005.

^* This work was supported in part by the U.S. Department of Agriculture and NIDDK, National Institutes of Health. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ Supported by a Canadian Institute for Health Research doctoral fellowship and a Woodrow-Wilson Johnson and Johnson Dissertation Fellowship for Research in Women's Health.

² To whom correspondence should be addressed. Tel.: 617-556-3144; Fax: 617-556-3224; E-mail: Andrew.greenberg{at}tufts.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. H. A. Ronkainen, V. Kovanen, M. Alen, E. Pollanen, E.-M. Palonen, C. Ankarberg-Lindgren, E. Hamalainen, U. Turpeinen, U. M. Kujala, J. Puolakka, et al. Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs J Appl Physiol, July 1, 2009; 107(1): 25 - 33. [Abstract] [Full Text] [PDF]

				G. R. Steinberg and B. E. Kemp AMPK in Health and Disease Physiol Rev, July 1, 2009; 89(3): 1025 - 1078. [Abstract] [Full Text] [PDF]

				L. D. Brewer, A. L. S. Dowling, M. A. Curran-Rauhut, P. W. Landfield, N. M. Porter, and E. M. Blalock Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats J. Neurosci., May 13, 2009; 29(19): 6058 - 6067. [Abstract] [Full Text] [PDF]

				N. H. Rogers, J. W. Perfield II, K. J. Strissel, M. S. Obin, and A. S. Greenberg Reduced Energy Expenditure and Increased Inflammation Are Early Events in the Development of Ovariectomy-Induced Obesity Endocrinology, May 1, 2009; 150(5): 2161 - 2168. [Abstract] [Full Text] [PDF]

				K. Guo, J. Mogen, S. Struzzi, and Y. Zhang Preadipocyte transplantation: an in vivo study of direct leptin signaling on adipocyte morphogenesis and cell size Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2009; 296(5): R1339 - R1347. [Abstract] [Full Text] [PDF]

				Y. Macotela, J. Boucher, T. T. Tran, and C. R. Kahn Sex and Depot Differences in Adipocyte Insulin Sensitivity and Glucose Metabolism Diabetes, April 1, 2009; 58(4): 803 - 812. [Abstract] [Full Text] [PDF]

				L. J. Rijzewijk, R. W. van der Meer, J. W.A. Smit, M. Diamant, J. J. Bax, S. Hammer, J. A. Romijn, A. de Roos, and H. J. Lamb Myocardial Steatosis Is an Independent Predictor of Diastolic Dysfunction in Type 2 Diabetes Mellitus. J. Am. Coll. Cardiol., November 25, 2008; 52(22): 1793 - 1799. [Abstract] [Full Text] [PDF]

				R. Monteiro, M. Assuncao, J. P. Andrade, D. Neves, C. Calhau, and I. Azevedo Chronic Green Tea Consumption Decreases Body Mass, Induces Aromatase Expression, and Changes Proliferation and Apoptosis in Adult Male Rat Adipose Tissue J. Nutr., November 1, 2008; 138(11): 2156 - 2163. [Abstract] [Full Text] [PDF]

				G. Bryzgalova, L. Lundholm, N. Portwood, J.-A. Gustafsson, A. Khan, S. Efendic, and K. Dahlman-Wright Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice Am J Physiol Endocrinol Metab, October 1, 2008; 295(4): E904 - E912. [Abstract] [Full Text] [PDF]

				C. S Wyrwoll, P. J Mark, T. A Mori, and B. J Waddell Developmental programming of adult hyperinsulinemia, increased proinflammatory cytokine production, and altered skeletal muscle expression of SLC2A4 (GLUT4) and uncoupling protein 3 J. Endocrinol., September 1, 2008; 198(3): 571 - 579. [Abstract] [Full Text] [PDF]

				R. W. van der Meer, S. Hammer, H. J. Lamb, M. Frolich, M. Diamant, L. J. Rijzewijk, A. de Roos, J. A. Romijn, and J. W. A. Smit Effects of Short-Term High-Fat, High-Energy Diet on Hepatic and Myocardial Triglyceride Content in Healthy Men J. Clin. Endocrinol. Metab., July 1, 2008; 93(7): 2702 - 2708. [Abstract] [Full Text] [PDF]

				R. W. van der Meer, L. J. Rijzewijk, M. Diamant, S. Hammer, M. Schar, J. J. Bax, J. W.A. Smit, J. A. Romijn, A. de Roos, and H. J. Lamb The ageing male heart: myocardial triglyceride content as independent predictor of diastolic function Eur. Heart J., June 2, 2008; 29(12): 1516 - 1522. [Abstract] [Full Text] [PDF]

				S. Sajapitak, K. Iwata, M. Shahab, Y. Uenoyama, S. Yamada, M. Kinoshita, F. Y. Bari, H. I'Anson, H. Tsukamura, and K.-i. Maeda Central Lipoprivation-Induced Suppression of Luteinizing Hormone Pulses Is Mediated by Paraventricular Catecholaminergic Inputs in Female Rats Endocrinology, June 1, 2008; 149(6): 3016 - 3024. [Abstract] [Full Text] [PDF]

				T. M. D'Eon, K. A. Pierce, J. J. Roix, A. Tyler, H. Chen, and S. R. Teixeira The Role of Adipocyte Insulin Resistance in the Pathogenesis of Obesity-Related Elevations in Endocannabinoids Diabetes, May 1, 2008; 57(5): 1262 - 1268. [Abstract] [Full Text] [PDF]

				C. R. Cederroth, M. Vinciguerra, A. Gjinovci, F. Kuhne, M. Klein, M. Cederroth, D. Caille, M. Suter, D. Neumann, R. W. James, et al. Dietary Phytoestrogens Activate AMP-Activated Protein Kinase With Improvement in Lipid and Glucose Metabolism Diabetes, May 1, 2008; 57(5): 1176 - 1185. [Abstract] [Full Text] [PDF]

				L. Lundholm, M. Putnik, M. Otsuki, S. Andersson, C. Ohlsson, J.-A. Gustafsson, and K. Dahlman-Wright Effects of estrogen on gene expression profiles in mouse hypothalamus and white adipose tissue: target genes include glutathione peroxidase 3 and cell death-inducing DNA fragmentation factor, {alpha}-subunit-like effector A J. Endocrinol., March 1, 2008; 196(3): 547 - 557. [Abstract] [Full Text] [PDF]

				D. Zhou, R. Shen, J. J. Ye, Y. Li, W. Tsark, D. Isbell, P. Tso, and S. Chen Nuclear Receptor Coactivator PNRC2 Regulates Energy Expenditure and Adiposity J. Biol. Chem., January 4, 2008; 283(1): 541 - 553. [Abstract] [Full Text] [PDF]

				J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]

				K. J. Strissel, Z. Stancheva, H. Miyoshi, J. W. Perfield II, J. DeFuria, Z. Jick, A. S. Greenberg, and M. S. Obin Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications Diabetes, December 1, 2007; 56(12): 2910 - 2918. [Abstract] [Full Text] [PDF]

				S. R. Thorn, M. J. Meyer, M. E. Van Amburgh, and Y. R. Boisclair Effect of Estrogen on Leptin and Expression of Leptin Receptor Transcripts in Prepubertal Dairy Heifers J Dairy Sci, August 1, 2007; 90(8): 3742 - 3750. [Abstract] [Full Text] [PDF]

				M. E. Wierman and W. M. Kohrt Review Article: Vascular and Metabolic Effects of Sex Steroids: New Insights Into Clinical Trials Reproductive Sciences, May 1, 2007; 14(4): 300 - 314. [Abstract] [PDF]

				I. Larosche, P. Letteron, B. Fromenty, N. Vadrot, A. Abbey-Toby, G. Feldmann, D. Pessayre, and A. Mansouri Tamoxifen Inhibits Topoisomerases, Depletes Mitochondrial DNA, and Triggers Steatosis in Mouse Liver J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 526 - 535. [Abstract] [Full Text] [PDF]

				A.-M. Jaubert, N. Mehebik-Mojaat, D. Lacasa, D. Sabourault, Y. Giudicelli, and C. Ribiere Nongenomic Estrogen Effects on Nitric Oxide Synthase Activity in Rat Adipocytes Endocrinology, May 1, 2007; 148(5): 2444 - 2452. [Abstract] [Full Text] [PDF]

				M. E. Trujillo and P. E. Scherer Adipose Tissue-Derived Factors: Impact on Health and Disease Endocr. Rev., December 1, 2006; 27(7): 762 - 778. [Abstract] [Full Text] [PDF]

				K. J. McInnes, A. Corbould, E. R. Simpson, and M. E. Jones Regulation of Adenosine 5',Monophosphate-Activated Protein Kinase and Lipogenesis by Androgens Contributes to Visceral Obesity in an Estrogen-Deficient State Endocrinology, December 1, 2006; 147(12): 5907 - 5913. [Abstract] [Full Text] [PDF]

				J. L. Turgeon, M. C. Carr, P. M. Maki, M. E. Mendelsohn, and P. M. Wise Complex Actions of Sex Steroids in Adipose Tissue, the Cardiovascular System, and Brain: Insights from Basic Science and Clinical Studies Endocr. Rev., October 1, 2006; 27(6): 575 - 605. [Abstract] [Full Text] [PDF]

				H.-P. H. Moore, R. B. Silver, E. P. Mottillo, D. A. Bernlohr, and J. G. Granneman Perilipin Targets a Novel Pool of Lipid Droplets for Lipolytic Attack by Hormone-sensitive Lipase J. Biol. Chem., December 30, 2005; 280(52): 43109 - 43120. [Abstract] [Full Text] [PDF]