HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 280, Issue 45, 37377-37382, November 11, 2005

This Article Full Text Full Text (PDF) All Versions of this Article: 280/45/37377    most recent M508246200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marambaud, P. Articles by Davies, P. Search for Related Content PubMed PubMed Citation Articles by Marambaud, P. Articles by Davies, P. Social Bookmarking                      What's this?

Resveratrol Promotes Clearance of Alzheimer's Disease Amyloid- Peptides^*

From the Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, North Shore-Long Island Jewish Institute for Medical Research, Manhasset, New York 11030

Several epidemiological studies indicate that moderate consumption of wine is associated with a lower incidence of Alzheimer's disease. Wine is enriched in antioxidant compounds with potential neuroprotective activities. However, the exact molecular mechanisms involved in the beneficial effects of wine intake on the neurodegenerative process in Alzheimer's disease brain remain to be clearly defined. Here we show that resveratrol (trans-3,4',5-trihydroxystilbene), a naturally occurring polyphenol mainly found in grapes and red wine, markedly lowers the levels of secreted and intracellular amyloid- (A) peptides produced from different cell lines. Resveratrol does not inhibit A production, because it has no effect on the A-producing enzymes - and -secretases, but promotes instead intracellular degradation of A via a mechanism that involves the proteasome. Indeed, the resveratrol-induced decrease of A could be prevented by several selective proteasome inhibitors and by siRNA-directed silencing of the proteasome subunit 5. These findings demonstrate a proteasome-dependent anti-amyloidogenic activity of resveratrol and suggest that this natural compound has a therapeutic potential in Alzheimer's disease.

Received for publication, July 27, 2005 , and in revised form, September 12, 2005.

^* This work was supported by National Institute of Mental Health Grant 38623 and by a grant from the American Health Assistance Foundation. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ To whom correspondence should be addressed: The Litwin-Zucker Research Center for the Study of Alzheimer's Disease and Memory Disorders, North Shore-Long Island Jewish Institute for Medical Research, 350 Community Dr., Manhasset, NY 11030. Tel.: 516-562-3492; E-mail: pmaramba{at}aecom.yu.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. Catoire, M. Y. Pasco, A. Abu-Baker, S. Holbert, C. Tourette, B. Brais, G. A. Rouleau, J. A. Parker, and C. Neri Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1 Hum. Mol. Genet., July 15, 2008; 17(14): 2108 - 2117. [Abstract] [Full Text] [PDF]

				M. Bacher, R. Dodel, B. Aljabari, K. Keyvani, P. Marambaud, R. Kayed, C. Glabe, N. Goertz, A. Hoppmann, N. Sachser, et al. CNI-1493 inhibits A{beta} production, plaque formation, and cognitive deterioration in an animal model of Alzheimer's disease J. Exp. Med., July 7, 2008; 205(7): 1593 - 1599. [Abstract] [Full Text] [PDF]

				J. Wang, L. Ho, W. Zhao, K. Ono, C. Rosensweig, L. Chen, N. Humala, D. B. Teplow, and G. M. Pasinetti Grape-Derived Polyphenolics Prevent A{beta} Oligomerization and Attenuate Cognitive Deterioration in a Mouse Model of Alzheimer's Disease J. Neurosci., June 18, 2008; 28(25): 6388 - 6392. [Abstract] [Full Text] [PDF]

				J. Wang, L. Ho, Z. Zhao, I. Seror, N. Humala, D. L. Dickstein, M. Thiyagarajan, S. S. Percival, S. T. Talcott, and G. M. Pasinetti Moderate consumption of Cabernet Sauvignon attenuates A{beta} neuropathology in a mouse model of Alzheimer's disease FASEB J, November 1, 2006; 20(13): 2313 - 2320. [Abstract] [Full Text] [PDF]

				C. L. Masters and K. Beyreuther Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the A{beta} amyloid pathway Brain, November 1, 2006; 129(11): 2823 - 2839. [Abstract] [Full Text] [PDF]

				G. Weissmann Dietary supplements: red wine, ortolans, and chondroitin sulfate FASEB J, May 1, 2006; 20(7): 803 - 805. [Full Text] [PDF]