Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     


Originally published In Press as doi:10.1074/jbc.M511629200 on January 5, 2006

J. Biol. Chem., Vol. 281, Issue 11, 7082-7088, March 17, 2006
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow All Versions of this Article:
281/11/7082    most recent
M511629200v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wills, N. M.
Right arrow Articles by Atkins, J. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wills, N. M.
Right arrow Articles by Atkins, J. F.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

A Functional –1 Ribosomal Frameshift Signal in the Human Paraneoplastic Ma3 Gene*Formula

Norma M. Wills{ddagger}, Barry Moore{ddagger}, Andrew Hammer{ddagger}, Raymond F. Gesteland{ddagger}, and John F. Atkins{ddagger}§1

From the {ddagger}Department of Human Genetics, University of Utah, Salt Lake City, Utah 84112 and the §Biosciences Institute, University College Cork, Cork, Ireland

A bioinformatics approach to finding new cases of –1 frameshifting in the expression of human genes revealed a classical retrovirus-like heptanucleotide shift site followed by a potential structural stimulator in the paraneoplastic antigen Ma3 and Ma5 genes. Analysis of the sequence 3' of the shift site demonstrated that an RNA pseudoknot in Ma3 is important for promoting efficient –1 frame-shifting. Ma3 is a member of a family of six genes in humans whose protein products contain homology to retroviral Gag proteins. The –1 frameshift site and pseudoknot structure are conserved in other mammals, but there are some sequence differences. Although the functions of the Ma genes are unknown, the serious neurological effects of ectopic expression in tumor cells indicate their importance in the brain.


Received for publication, October 27, 2005 , and in revised form, January 4, 2006.

Note Added in Proof—A recent study has independently grouped the six human Ma genes in a family (Schüller, M., Jenne, D., and Voltz, R. (2005) J. Neuroimmunol. 169, 172–176).

* This work was supported by National Institutes of Health Grants GM71853 (to R. F. G.) and GM48152 (to J. F. A.), who was also supported by an award from Science Foundation Ireland. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Formula The on-line version of this article (available at http://www.jbc.org) contains supplemental Table S2.

1 To whom correspondence should be addressed: Dept. of Human Genetics, 15 N. 2030 E., Bldg. 533, Rm. 7410, Salt Lake City, UT 84112-5330. Tel.: 801-585-3434; Fax: 801-585-3910; E-mail: john.atkins{at}genetics.utah.edu.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
J. Biol. Chem.Home page
M. B. Clark, M. Janicke, U. Gottesbuhren, T. Kleffmann, M. Legge, E. S. Poole, and W. P. Tate
Mammalian Gene PEG10 Expresses Two Reading Frames by High Efficiency 1 Frameshifting in Embryonic-associated Tissues
J. Biol. Chem., December 28, 2007; 282(52): 37359 - 37369.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
I. P. Ivanov and J. F. Atkins
Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation
Nucleic Acids Res., March 19, 2007; 35(6): 1842 - 1858.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
J. L. Jacobs, A. T. Belew, R. Rakauskaite, and J. D. Dinman
Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae
Nucleic Acids Res., January 12, 2007; 35(1): 165 - 174.
[Abstract] [Full Text] [PDF]


Home page
Nucleic Acids ResHome page
B. Cobucci-Ponzano, F. Conte, D. Benelli, P. Londei, A. Flagiello, M. Monti, P. Pucci, M. Rossi, and M. Moracci
The gene of an archaeal {alpha}-L-fucosidase is expressed by translational frameshifting
Nucleic Acids Res., September 10, 2006; 34(15): 4258 - 4268.
[Abstract] [Full Text] [PDF]


Home page
RNAHome page
N. M. Wills and J. F. Atkins
The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases
RNA, July 1, 2006; 12(7): 1149 - 1153.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2006 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement