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J. Biol. Chem., Vol. 281, Issue 14, 9482-9489, April 7, 2006

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1,4-Galactosyltransferase V Functions as a Positive Growth Regulator in Glioma^*

From the Key Laboratory of Medical Molecular Virology Ministry of Education and Health, Gene Research Center, Shanghai Medical College of Fudan University (former Shanghai Medical University), Shanghai 200032, China

1,4-galactosyltransferase V (GalT V; EC 2.4.1.38 [EC] ) can effectively galactosylate the GlcNAc16Man arm of the highly branched N-glycans that are characteristic of glioma. Previously, we have reported that the expression of GalT V is increased in the process of glioma. However, currently little is known about the role of GalT V in this process. In this study, the ectopic expression of GalT V could promote the invasion and survival of glioma cells and transformed astrocytes. Furthermore, decreasing the expression of GalT V in glioma cells promoted apoptosis, inhibited the invasion and migration and the ability of tumor formation in vivo, and reduced the activation of AKT. In addition, the activity of GalT V promoter could be induced by epidermal growth factor, dominant active Ras, ERK1, JNK1, and constitutively active AKT. Taken together, our results suggest that GalT V functioned as a novel glioma growth activator and might represent a novel target in glioma therapy.

Received for publication, April 25, 2005 , and in revised form, February 3, 2006.

^* This work was supported by the 863 Program of China (2001AA234031) and the National Natural Scientific Foundation of China (30330320) and a grant from the development of science and technology of Shanghai (02DJ14002). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ To whom correspondence should be addressed. Tel.: 86-21-54237704; Fax: 86-21-64164489; E-mail: jxgu{at}shmu.edu.cn.

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