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J. Biol. Chem., Vol. 281, Issue 22, 15033-15036, June 2, 2006

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hSnm1B Is a Novel Telomere-associated Protein^*

From the Department of Pharmacology and Cancer Biology, Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710

Artemis, a member of the -CASP family, has been implicated in the regulation of both telomere stability and length. Prompted by this, we examined whether the other two putative DNA-binding members of this family, hSnm1A and hSnm1B, may associate with telomeres. hSnm1A was found to not interact with the telomere. Conversely, hSnm1B was found to associate with telomeres in vivo by both immunofluorescence and chromatin immunoprecipitation. Furthermore, the C terminus of hSnm1B was shown to interact with the TRF homology domain of TRF2 indicating that hSnm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2.

Received for publication, February 21, 2006

^* This work was supported by National Institutes of Health Grant CA82481. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ A Leukemia and Lymphoma Society Scholar. To whom correspondence should be addressed. Tel.: 919-684-9890; Fax: 919-684-8958; E-mail: count004{at}mc.duke.edu.

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