HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 281, Issue 24, 16189-16192, June 16, 2006

This Article Full Text Full Text (PDF) All Versions of this Article: 281/24/16189    most recent R600003200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sallee, J. L. Articles by Burridge, K. Search for Related Content PubMed PubMed Citation Articles by Sallee, J. L. Articles by Burridge, K. Social Bookmarking                      What's this?

Minireview

Regulation of Cell Adhesion by Protein-tyrosine Phosphatases

II. CELL-CELL ADHESION^*

From the Department of Cell and Developmental Biology and Lineberger Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599-7295

Cell-cell adhesion is critical to the development and maintenance of multicellular organisms. The stability of many adhesions is regulated by protein tyrosine phosphorylation of cell adhesion molecules and their associated components, with high levels of phosphorylation promoting disassembly. The level of tyrosine phosphorylation reflects the balance between protein-tyrosine kinase and protein-tyrosine phosphatase activity. Many protein-tyrosine phosphatases associate with the cadherin-catenin complex, directly regulating the phosphorylation of these proteins, thereby affecting their interactions and the integrity of cell-cell junctions. Tyrosine phosphatases can also affect cell-cell adhesions indirectly by regulating the signaling pathways that control the activities of Rho family G proteins. In addition, receptor-type tyrosine phosphatases can mediate outside-in signaling through both ligand binding and dimerization of their extracellular domains. This review will discuss the role of protein-tyrosine phosphatases in cell-cell interactions, with an emphasis on cadherin-mediated adhesions.

^* This minireview will be reprinted in the 2006 Minireview Compendium, which will be available in January, 2007. This work was supported in part by National Institutes of Health Grants GM29860 and HL45100. This is Paper II in the series "Regulation of Cell Adhesion by Protein-tyrosine Phosphatases." Ref. 2 is Paper I in this series.

¹ Holds a predoctoral fellowship from the American Heart Association.

² Holds a postdoctoral fellowship from the Canadian Institutes for Health Research.

³ To whom correspondence should be addressed: Dept. of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7295. Tel.: 919-966-5783; E-mail: keith_burridge{at}med.unc.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J. L. Sallee and K. Burridge Density-enhanced Phosphatase 1 Regulates Phosphorylation of Tight Junction Proteins and Enhances Barrier Function of Epithelial Cells J. Biol. Chem., May 29, 2009; 284(22): 14997 - 15006. [Abstract] [Full Text] [PDF]

				F. Fuentes and C. O. Arregui Microtubule and Cell Contact Dependency of ER-bound PTP1B Localization in Growth Cones Mol. Biol. Cell, March 15, 2009; 20(6): 1878 - 1889. [Abstract] [Full Text] [PDF]

				H. Sadakata, H. Okazawa, T. Sato, Y. Supriatna, H. Ohnishi, S. Kusakari, Y. Murata, T. Ito, U. Nishiyama, T. Minegishi, et al. SAP-1 is a microvillus-specific protein tyrosine phosphatase that modulates intestinal tumorigenesis Genes Cells, March 1, 2009; 14(3): 295 - 308. [Abstract] [Full Text] [PDF]

				S.-H. Lee, I.-F. Peng, Y. G. Ng, M. Yanagisawa, S. X. Bamji, L. P. Elia, J. Balsamo, J. Lilien, P. Z. Anastasiadis, E. M. Ullian, et al. Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and {beta}-catenin J. Cell Biol., December 2, 2008; 183(5): 893 - 908. [Abstract] [Full Text] [PDF]

				Y. Nakamura, N. Patrushev, H. Inomata, D. Mehta, N. Urao, H. W. Kim, M. Razvi, V. Kini, K. Mahadev, B. J. Goldstein, et al. Role of Protein Tyrosine Phosphatase 1B in Vascular Endothelial Growth Factor Signaling and Cell-Cell Adhesions in Endothelial Cells Circ. Res., May 23, 2008; 102(10): 1182 - 1191. [Abstract] [Full Text] [PDF]

				A. Carlucci, C. Gedressi, L. Lignitto, L. Nezi, E. Villa-Moruzzi, E. V. Avvedimento, M. Gottesman, C. Garbi, and A. Feliciello Protein-tyrosine Phosphatase PTPD1 Regulates Focal Adhesion Kinase Autophosphorylation and Cell Migration J. Biol. Chem., April 18, 2008; 283(16): 10919 - 10929. [Abstract] [Full Text] [PDF]

				L. Carramusa, C. Ballestrem, Y. Zilberman, and A. D. Bershadsky Mammalian diaphanous-related formin Dia1 controls the organization of E-cadherin-mediated cell-cell junctions J. Cell Sci., November 1, 2007; 120(21): 3870 - 3882. [Abstract] [Full Text] [PDF]

				A. R. Aricescu, C. Siebold, K. Choudhuri, V. T. Chang, W. Lu, S. J. Davis, P. A. van der Merwe, and E. Y. Jones Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism Science, August 31, 2007; 317(5842): 1217 - 1220. [Abstract] [Full Text] [PDF]

				K. Burridge, S. K. Sastry, and J. L. Sallee Regulation of Cell Adhesion by Protein-tyrosine Phosphatases: I. CELL-MATRIX ADHESION J. Biol. Chem., June 9, 2006; 281(23): 15593 - 15596. [Abstract] [Full Text] [PDF]