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J. Biol. Chem., Vol. 281, Issue 3, 1389-1393, January 20, 2006
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RI, Is Revealed by SSL7 Binding at the C2/C3 Interface of IgA*
1
From the
Helen Macpherson Smith Trust Inflammatory Disease Laboratory, The Austin Research Institute, Austin Health, Heidelberg, Victoria 3084, Australia and The School of Medical Sciences, University of Auckland, Private Bag 92019, Auckland 1020, New Zealand
Leukocyte recruitment and effector functions like phagocytosis and respiratory burst are key elements of immunity to infection. Pathogen survival is dependent upon the ability to overwhelm, evade or inhibit the immune system. Pathogenic group A and group B streptococci are well known to produce virulence factors that block the binding of IgA to the leukocyte IgA receptor, Fc
RI, thereby inhibiting IgA-mediated immunity. Recently we found Staphylococcus aureus also interferes with IgA-mediated effector functions as the putative virulence factor SSL7 also binds IgA and blocks binding to FcRI. Herein we report that SSL7 and FcRI bind many of the same key residues in the Fc region of human IgA. Residues Leu-257 and Leu-258 in domain C2 and residues 440–443 PLAF in C3 of IgA lie at the C2/C3 interface and make major contributions to the binding of both the leukocyte receptor FcRI and SSL7. It is remarkable this S. aureus IgA binding factor and unrelated factors from streptococci are functionally convergent, all targeting a number of the same residues in the IgA Fc, which comprise the binding site for the leukocyte IgA receptor, FcRI.
Received for publication, August 24, 2005 , and in revised form, November 14, 2005.
* Supported by Grants 181627/315525 from the National Health and Medical Research Council. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 To whom correspondence should be addressed: Austin Research Institute, Austin Health, Studley Rd., Heidelberg, Victoria 3084, Australia. Tel.: 613-9287-0644; Fax: 613-9287-0600; E-mail: b.wines{at}ari.unimelb.edu.au.
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