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J. Biol. Chem., Vol. 281, Issue 31, 21690-21697, August 4, 2006

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Neuregulins Mediate Calcium-induced Glucose Transport during Muscle Contraction^*

Carles Cantó¹, Alexander V. Chibalin, Brian R. Barnes, Stephan Glund, Elisabet Suárez, Jeffrey W. Ryder, Manuel Palacín, Juleen R. Zierath, Antonio Zorzano, and Anna Gumà²

From the Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, and Institut de Recerca Biomèdica, Parc Científic de Barcelona, E-08028 Barcelona, Spain and the Karolinska Institutet, Department of Molecular Medicine and Surgery, Section of Integrative Physiology, SE-171 77 Stockholm, Sweden

Neuregulin, a growth factor involved in myogenesis, has rapid effects on muscle metabolism. In a manner analogous to insulin and exercise, neuregulins stimulate glucose transport through recruitment of glucose transporters to surface membranes in skeletal muscle. Like muscle contraction, neuregulins have additive effects with insulin on glucose uptake. Therefore, we examined whether neuregulins are involved in the mechanism by which muscle contraction regulates glucose transport. We show that caffeine-induced increases in cytosolic Ca²⁺ mediate a metalloproteinase-dependent release of neuregulins, which stimulates tyrosine phosphorylation of ErbB4 receptors. Activation of ErbB4 is necessary for Ca²⁺-derived effects on glucose transport. Furthermore, blockage of ErbB4 abruptly impairs contraction-induced glucose uptake in slow twitch muscle fibers, and to a lesser extent, in fast twitch muscle fibers. In conclusion, we provide evidence that contraction-induced activation of neuregulin receptors is necessary for the stimulation of glucose transport and a key element of energetic metabolism during muscle contraction.

Received for publication, January 17, 2006 , and in revised form, May 24, 2006.

^* This research was supported by the National Biomedicine Plan of the Spanish Ministry of Education and Science Grants SAF2002-01585 and SAF2005-00489 (to A. G.) and Grant SAF2005-00445 (to A. Z.), the Spanish Health Institute Carlos III (Grants RCMN C03/08, RGDM G03/212, and RGTO G02/028), Grant 2005SGR00947 from the Department of Universities of the Generalitat de Catalunya (to A. Z.), the Swedish Research Council, the Swedish Diabetes Association, the Foundation for Scientific Studies of Diabetology, the Strategic Research Foundation, the Swedish Centre for Sports Research, Contract LSHM-CT-2004-005272 EXGENESIS from the Commission of the European Community (to J. R. Z.). The Spanish group is member of the Network for Cooperative Research on Membrane Transport Proteins, co-funded by the Ministry of Education and Science, Spain and the European Regional Development Fund (Grant BFU2005-24983-E/BFI). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ A recipient of a postgraduate fellowship Formación de Personal Universitario (FPU) from the Spanish Ministry of Education and Science.

² To whom correspondence should be addressed: Departament Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Avda. Diagonal, 645, E-08028-Barcelona, Spain. Tel.: 34-93-4034600; Fax: 34-93-4021559; E-mail: aguma{at}ub.edu.

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