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J. Biol. Chem., Vol. 281, Issue 46, 34725-34729, November 17, 2006

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Minireview

The Ins and Outs of MYC Regulation by Posttranslational Mechanisms^*

From the Abteilung Biochemie und Molekularbiologie, Institut für Biochemie, Klinikum, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany

The proteins of the MYC family are key regulators of cell behavior. MYC, originally identified as an oncoprotein, affects growth, proliferation, differentiation, and apoptosis of cells through its ability to regulate a significant number of genes. In addition MYC governs events associated with tumor progression, including genetic stability, migration, and angiogenesis. The pleiotropic activities attributed to MYC and their balanced control requires that the expression and function of MYC is tightly controlled. Indeed many different pathways and factors have been identified that impinge on MYC gene expression and protein function. In particular the protein is subject to different posttranslational modifications, including phosphorylation, ubiquitinylation, and acetylation. Here we discuss the latest developments regarding these modifications that control various aspects of MYC function, including its stability, the interaction with partner proteins, and the transcriptional potential.

^* This minireview will be reprinted in the 2006 Minireview Compendium, which will be available in January, 2007. Work in our laboratory was supported by the Deutsche Forschungsgemeinschaft.

The online version of this article (available at http://www.jbc.org) contains supplemental Figs. S1 and S2 and Refs. 1–14.

¹ To whom correspondence should be addressed. Tel.: 49-241-8088841; Fax: 49-241-8888427; E-mail: luescher{at}rwth-aachen.de.

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