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J. Biol. Chem., Vol. 281, Issue 52, 40330-40340, December 29, 2006

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Deficiency of the Zinc Finger Protein ZPR1 Causes Defects in Transcription and Cell Cycle Progression^*

From the Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605

The zinc finger protein ZPR1 is present in both the cytoplasm and nucleoplasm. Cell cycle analysis demonstrates that ZPR1 undergoes major changes in subcellular distribution during proliferation. ZPR1 is diffusely localized throughout the cell during the G₁ and G₂/M phases of the cell cycle. In contrast, ZPR1 redistributes to the nucleus during S phase and ZPR1 exhibits prominent co-localization with the survival motor neurons protein and the histone gene-specific transcription factor NPAT in subnuclear foci, including Cajal bodies that associate with histone gene clusters. ZPR1 deficiency causes disruption of survival motor neurons and NPAT localization within the nucleus, blocks S phase progression, and arrests cells in both the G₁ and G₂ phases of the cell cycle. These changes in subnuclear architecture and cell cycle progression may be caused by transcriptional defects in ZPR1-deficient cells, including decreased histone gene expression.

Received for publication, August 24, 2006 , and in revised form, October 24, 2006.

^* This work was supported by grants from the Families of Spinal Muscular Atrophy and the Muscular Dystrophy Association (to L. G.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ To whom correspondence should be addressed: 373 Plantation St., Worcester, MA 01605. Tel.: 508-856-7844; Fax: 508-856-3210; E-mail: laxman.gangwani{at}umassmed.edu.

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				A. K. Mishra, L. Gangwani, R. J. Davis, and D. G. Lambright Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes PNAS, August 28, 2007; 104(35): 13930 - 13935. [Abstract] [Full Text] [PDF]