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J. Biol. Chem., Vol. 282, Issue 17, 12458-12466, April 27, 2007
Thyroid Hormone Response Element Organization Dictates the Composition of Active Receptor* 1![]() 1![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() 2 3 4
From the
Thyroid hormone (triiodothyronine, T3) is known to activate transcription by binding heterodimers of thyroid hormone receptors (TRs) and retinoid X receptors (RXRs). RXR-TRs bind to T3 response elements (TREs) composed of direct repeats of the sequence AGGTCA spaced by four nucleotides (DR-4). In other TREs, however, the half-sites can be arranged as inverted palindromes and palindromes (Pal). Here we show that TR homodimers and monomers activate transcription from representative TREs with alternate half-site placements. TR
Received for publication, November 17, 2006 , and in revised form, February 15, 2007. * This work was supported by Brazilian Research Council Grants CNPq/PADCT SBIO 620003/02-2 and CNPq 40.00.43/02-5, National Institutes of Health Grants DK41482, DK51281, and DK61468 (to J. D. B.), Canadian Institutes of Health Operational Grant MOP-49448, The Mount Sinai Hospital Foundation of Toronto and Department of Medicine Research Funds, and The Julius Kuhl and Temmy Latner/Dynacare Family Foundations (to P. G. W.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 1 Both authors contributed equally to this work. 2 Consultant to Karo Bio AB, a biotechnology company with commercial interests in nuclear receptors. 3 To whom correspondence may be addressed. Tel.: 415-476-6789; Fax: 415-564-5813; E-mail: pwebb{at}diabetes.ucsf.edu. 4 To whom correspondence may be addressed: Laboratorio de Farmacologia Molecular, Dept. de Ciências Farmacêuticas, Universidade de Brasília, Caixa Postal 4473, 70919-970, Brasília DF, Brazil. Tel.: 55-61-3072098; Fax: 55-61-3474622; E-mail: chico{at}unb.Br.
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