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J. Biol. Chem., Vol. 282, Issue 17, 12791-12795, April 27, 2007

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Collagen XXVII Is Developmentally Regulated and Forms Thin Fibrillar Structures Distinct from Those of Classical Vertebrate Fibrillar Collagens^*

Darren A. Plumb¹, Vivek Dhir, Aleksandr Mironov, Laila Ferrara, Richard Poulsom, Karl E. Kadler, David J. Thornton, Michael D. Briggs, and Raymond P. Boot-Handford²

From the Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and the Histopathology Unit, Cancer Research UK London Research Institute, London WC2A 3PX, United Kingdom

We have generated an antiserum to the variable domain of mouse collagen XXVII, a recently discovered novel member of the fibrillar collagen family. Collagen XXVII protein was first detectable in the mouse at embryonic day 12.5 (E12.5). By E14.5, the protein localized to cartilage, developing dermis, cornea, the inner limiting membrane of the retina, and major arteries of the heart. However, at E18.5, collagen XXVII protein was no longer apparent in most tissues and appeared restricted mainly to cartilage where expression continued into adulthood. Type XXVII collagen immunolocalized to 10-nm-thick nonstriated fibrils that were distinct from fibrils formed by the classical fibrillar collagens. The transient nature of its expression and unusual fibrillar structure suggest that collagen XXVII plays a developmental role distinct from those of the classical fibrillar collagens.

Received for publication, January 31, 2007

^* This work was funded in part by Grants 15967 and 17243 from the Arthritis Research Campaign and by the National Institutes of Health. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement"in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The on-line version of this article (available at http://www.jbc.org) contains supplemental Figs. S1–S4.

¹ Recipient of a Medical Research Council Ph.D. studentship.

² To whom correspondence should be addressed: Wellcome Trust Centre for Cell-Matrix Research, Faculty of Life Sciences, The University of Manchester, Manchester M13 9PT, United Kingdom. Tel.: 0044-161-275-5097; Fax: 0044-161-275-5082; E-mail: ray.boot-handford{at}manchester.ac.uk.

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