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J. Biol. Chem., Vol. 282, Issue 17, 13087-13097, April 27, 2007

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Identification and Characterization of a New Class of Trafficking Motifs for Controlling Clathrin-independent Internalization and Recycling^*

Qiang Gong, Michael Weide, Christopher Huntsman, Zhuojin Xu, Lily Y. Jan, and Dzwokai Ma^¶1

From the Department of Molecular, Cellular, and Developmental Biology and ^¶Neuroscience Research Institute, University of California, Santa Barbara, California 93106 and the Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, California 94143

Plasma membrane proteins such as receptors and ion channels allow a cell to communicate with its environment and regulate many intracellular activities. Thus, the proper control of the surface number of these proteins is essential for maintaining the structural and functional homeostasis of a cell. Internalization and recycling plays a key role in determining the surface density of receptors and channels. Whereas the clathrin-mediated internalization and its associated recycling have been the focus of research in this field, recent studies have revealed that an increasing number of receptors and channels enter a cell via clathrin-independent pathways. However, little is known about the trafficking motifs involved in controlling clathrin-independent internalization and various associated recycling pathways. By using a potassium channel as a model system, we identified a class of trafficking motifs that function along a clathrin-independent pathway to increase the surface density of a membrane protein by preventing its rapid internalization and/or facilitating its recycling via the ADP-ribosylation factor 6-dependent recycling pathway. Moreover our data suggest that these motifs may enhance the association of membrane proteins with the EFA6 family of guanine nucleotide exchange factors for ADP-ribosylation factor 6.

Received for publication, January 26, 2007

^* The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ To whom correspondence should be addressed. Tel.: 805-893-4745; E-mail: ma{at}lifesci.ucsb.edu.

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