|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 282, Issue 21, 15319-15323, May 25, 2007
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Minireview
Toll-like Receptors and Type I Interferons*
1
From the
Department of Host Defense, Research Institute for Microbial Diseases, Osaka University and ERATO, Japan Science and Technology Corporation, 3-1 Yamada-oka, Suita Osaka 565-0871, Japan
Toll-like receptors (TLRs) are key molecules of the innate immune systems, which detect conserved structures found in a broad range of pathogens and trigger innate immune responses. A subset of TLRs recognizes viral components and induces antiviral responses. Whereas TLR4 recognizes viral components at the cell surface, TLR3, TLR7, TLR8, and TLR9 recognize viral nucleic acids on endosomal membrane. After ligand recognition, these members activate their intrinsic signaling pathways and induce type I interferon. In this review, we discuss the recent findings of the viral recognition by TLRs and their signaling pathways.
* This minireview will be reprinted in the 2007 Minireview Compendium, which will be available in January, 2008. This is the second article of three in the Innate Immunity Minireview Series.
1 To whom correspondence should be addressed. Tel.: 81-6-6879-8303; Fax: 81-6-6879-8305; E-mail: sakira{at}biken.osaka-u.ac.jp.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  A. F. de Vos, J. M. Pater, P. S. van den Pangaart, M. D. de Kruif, C. van 't Veer, and T. van der Poll In Vivo Lipopolysaccharide Exposure of Human Blood Leukocytes Induces Cross-Tolerance to Multiple TLR Ligands J. Immunol., July 1, 2009; 183(1): 533 - 542. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. D. Sadik, M. Bachmann, J. Pfeilschifter, and H. Muhl Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA Nucleic Acids Res., June 18, 2009; (2009) gkp525v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Zhang, J. O. Langland, B. L. Jacobs, and C. E. Samuel Protein Kinase PKR-Dependent Activation of Mitogen-Activated Protein Kinases Occurs through Mitochondrial Adapter IPS-1 and Is Antagonized by Vaccinia Virus E3L J. Virol., June 1, 2009; 83(11): 5718 - 5725. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Larrea, R. Aldabe, I. Gonzalez, V. Segura, P. Sarobe, I. Echeverria, and J. Prieto Oncostatin M Enhances the Antiviral Effects of Type I Interferon and Activates Immunostimulatory Functions in Liver Epithelial Cells J. Virol., April 1, 2009; 83(7): 3298 - 3311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Richter, M. H. S. Juan, J. Will, R. P. Brandes, U. Kalinke, S. Akira, J. M. Pfeilschifter, M. Hultqvist, R. Holmdahl, and H. H. Radeke Ncf1 Provides a Reactive Oxygen Species-Independent Negative Feedback Regulation of TLR9-Induced IL-12p70 in Murine Dendritic Cells J. Immunol., April 1, 2009; 182(7): 4183 - 4191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Sly, M. J. Hamilton, E. Kuroda, V. W. Ho, F. L. Antignano, S. L. Omeis, C. J. van Netten-Thomas, D. Wong, H. K. Brugger, O. Williams, et al. SHIP prevents lipopolysaccharide from triggering an antiviral response in mice Blood, March 26, 2009; 113(13): 2945 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yang, H.-X. Shi, X.-Y. Liu, Y.-F. Shan, B. Wei, S. Chen, and C. Wang TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response J. Immunol., March 15, 2009; 182(6): 3782 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. S. McAllister and C. E. Samuel The RNA-activated Protein Kinase Enhances the Induction of Interferon-{beta} and Apoptosis Mediated by Cytoplasmic RNA Sensors J. Biol. Chem., January 16, 2009; 284(3): 1644 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Sandanger, L. Ryan, J. Bohnhorst, A.-C. Iversen, H. Husebye, O. Halaas, L. Landro, P. Aukrust, S. S. Froland, G. Elson, et al. IL-10 Enhances MD-2 and CD14 Expression in Monocytes and the Proteins Are Increased and Correlated in HIV-Infected Patients J. Immunol., January 1, 2009; 182(1): 588 - 595. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. K. Pfaller and K.-K. Conzelmann Measles Virus V Protein Is a Decoy Substrate for I{kappa}B Kinase {alpha} and Prevents Toll-Like Receptor 7/9-Mediated Interferon Induction J. Virol., December 15, 2008; 82(24): 12365 - 12373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Zhang and C. E. Samuel Induction of Protein Kinase PKR-dependent Activation of Interferon Regulatory Factor 3 by Vaccinia Virus Occurs through Adapter IPS-1 Signaling J. Biol. Chem., December 12, 2008; 283(50): 34580 - 34587. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Daffis, M. A. Samuel, M. S. Suthar, M. Gale Jr., and M. S. Diamond Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection J. Virol., November 1, 2008; 82(21): 10349 - 10358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Ning, A. D. Campos, B. G. Darnay, G. L. Bentz, and J. S. Pagano TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Protein 1 Mol. Cell. Biol., October 15, 2008; 28(20): 6536 - 6546. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Le Tortorec, H. Denis, A-P. Satie, J-J. Patard, A. Ruffault, B. Jegou, and N. Dejucq-Rainsford Antiviral responses of human Leydig cells to mumps virus infection or poly I:C stimulation Hum. Reprod., September 1, 2008; 23(9): 2095 - 2103. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Pietras and G. Cheng A New TRADDition in Intracellular Antiviral Signaling Sci. Signal., July 29, 2008; 1(30): pe36 - pe36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Zeng, H. Li, Y. Liu, Z. Zhang, Y. Zhang, and R. Yang Tumor-Induced Suppressor of Cytokine Signaling 3 Inhibits Toll-like Receptor 3 Signaling in Dendritic Cells via Binding to Tyrosine Kinase 2 Cancer Res., July 1, 2008; 68(13): 5397 - 5404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Hayashi, H. B. Cottam, M. Chan, G. Jin, R. I. Tawatao, B. Crain, L. Ronacher, K. Messer, D. A. Carson, and M. Corr Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7 Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R123 - R132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ovstebo, O. K. Olstad, B. Brusletto, A. S. Moller, A. Aase, K. B. F. Haug, P. Brandtzaeg, and P. Kierulf Identification of Genes Particularly Sensitive to Lipopolysaccharide (LPS) in Human Monocytes Induced by Wild-Type versus LPS-Deficient Neisseria meningitidis Strains Infect. Immun., June 1, 2008; 76(6): 2685 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. G. Ramirez-Ortiz, C. A. Specht, J. P. Wang, C. K. Lee, D. C. Bartholomeu, R. T. Gazzinelli, and S. M. Levitz Toll-Like Receptor 9-Dependent Immune Activation by Unmethylated CpG Motifs in Aspergillus fumigatus DNA Infect. Immun., May 1, 2008; 76(5): 2123 - 2129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. J. Kang, J. Chen, M. Otsuka, J. Mols, S. Ren, Y. Wang, and J. Han Macrophage Deletion of p38{alpha} Partially Impairs Lipopolysaccharide-Induced Cellular Activation J. Immunol., April 1, 2008; 180(7): 5075 - 5082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Marafioti, J. C. Paterson, E. Ballabio, K. K. Reichard, S. Tedoldi, K. Hollowood, M. Dictor, M.-L. Hansmann, S. A. Pileri, M. J. Dyer, et al. Novel markers of normal and neoplastic human plasmacytoid dendritic cells Blood, April 1, 2008; 111(7): 3778 - 3792. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Behrens, W. M. Wagner, C. J. Krco, C. L. Erskine, K. R. Kalli, J. Krempski, E. A. Gad, M. L. Disis, and K. L. Knutson The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity Blood, February 1, 2008; 111(3): 1472 - 1479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. E. Samuel Interferons, Interferon Receptors, Signal Transducer and Transcriptional Activators, and Interferon Regulatory Factors J. Biol. Chem., July 13, 2007; 282(28): 20045 - 20046. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |