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J. Biol. Chem., Vol. 283, Issue 1, 453-460, January 4, 2008

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FoxM1 Regulates Growth Factor-induced Expression of Kinase-interacting Stathmin (KIS) to Promote Cell Cycle Progression^*

From the Department of Biochemistry and Molecular Genetics, University of Illinois College of Medicine, Chicago, Illinois 60607

The Forkhead box M1 (FoxM1) transcription factor is essential for cell cycle progression and mitosis. FoxM1 regulates expression of Skp2 and Cks1, subunits of the SCF ubiquitin ligase complex, which ubiquitinates p27^Kip1 and targets it for degradation. Kinase-interacting stathmin (KIS) is a growth factor-dependent nuclear kinase that regulates cell cycle progression by phosphorylating p27^Kip1 to promote its nuclear export. Here we present an additional mechanism of FoxM1-mediated regulation of p27^Kip1 and provide evidence that FoxM1 regulates growth factor-induced expression of KIS. In cells harboring FoxM1 deletion or expressing FoxM1-short interfering RNA, the expression of KIS is impaired, leading to an accumulation of p27^Kip1 in the nucleus. Furthermore, we show that KIS is a direct transcriptional target of FoxM1. Thus FoxM1 promotes cell cycle progression by down-regulating p27^Kip1 through multiple mechanisms.

Received for publication, July 16, 2007 , and in revised form, October 15, 2007.

^* This work was supported in part by National Institutes of Health Grants DK054687, AG021842, and CA124488 (to R. H. C.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ Supported by National Institutes of Health Grants CA46565 and AG21842.

² Supported by National Institutes of Health Grants CA124488 and CA100035.

³ Supported by National Institutes of Health Grants DK44525 and DK068503. To whom correspondence should be addressed: Dept. of Biochemistry and Molecular Genetics (M/C 669), University of Illinois College of Medicine, 900 S. Ashland Ave., Chicago, IL 60607. Tel.: 312-996-7964; Fax: 312-413-4892; E-mail: atyner{at}uic.edu.

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