HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 283, Issue 1, 541-553, January 4, 2008

This Article Full Text Full Text (PDF) All Versions of this Article: 283/1/541    most recent M703234200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Zhou, D. Articles by Chen, S. Search for Related Content PubMed PubMed Citation Articles by Zhou, D. Articles by Chen, S. Social Bookmarking                      What's this?

Nuclear Receptor Coactivator PNRC2 Regulates Energy Expenditure and Adiposity^*

Dujin Zhou¹, Ruoqing Shen¹, Jing Jing Ye, Yuping Li, Walter Tsark, Donna Isbell^¶, Patrick Tso^||2, and Shiuan Chen³

From the Department of Surgical Research, Transgenic Mouse Facility, and ^¶Animal Resources Center, Beckman Research Institute of City of Hope, Duarte, California 91010 and the ^||Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0529

PNRC2 was identified in our laboratory as a general cofactor for nuclear receptors. To better characterize the physiological function of PNRC2, we used gene-targeting technology to generate PNRC2-null mice (PNRC2^-/- mice). These PNRC2^-/- mice are viable and fertile. PNRC2-null mice, especially male mice, are lean and are resistant to high fat diet-induced obesity but without the induction of insulin resistance. Male mice devoid of PNRC2 protein have a higher metabolic rate than wild-type mice. They consume more oxygen and produce more heat. Consistent with reduced adipose mass, the levels of leptin are lower in PNRC2^-/- mice. This study provides evidence that PNRC2 plays one or more important roles in controlling the energy balance between energy storage and energy expenditure. PNRC2 may be a new target in the treatment of obesity and related metabolic diseases.

Received for publication, April 17, 2007 , and in revised form, October 9, 2007.

^* This work was supported in part by National Institutes of Health Grant DK60560 (to S. C.). The Transgenic Mouse Facility and the Animal Resources Center at the Beckman Research Institute of the City of Hope are supported by the City of Hope Comprehensive Cancer Center (Grant CA33572). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ Both authors contributed equally to this work.

² Supported by National Institutes of Health Grant DK59630.

³ To whom correspondence should be addressed: Tel.: 626-359-8111 (ext. 63454); Fax: 626-301-8972; E-mail: schen{at}coh.org.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?