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J. Biol. Chem., Vol. 283, Issue 26, 17749-17752, June 27, 2008

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Minireview

Expanded Roles for Chk1 in Genome Maintenance^*

From the Department of Medicine, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111

Chk1 is a conserved kinase that imposes cell cycle delays in response to impediments to DNA replication. Recent experiments have further defined effects of Chk1 on the activity of mammalian origins of DNA replication and progression of replication forks. Moreover, Chk1 now appears to help defend genomic integrity through effects on several other pathways, including Fanconi anemia proteins, the mitotic spindle, and transcription of cell cycle-related genes. These findings can account for the requirement for Chk1 in normal proliferating cells of the early embryo and suggest the potential for diverse effects of Chk1 inhibition in cancer therapy.

^* This work was supported, in whole or in part, by National Institutes of Health Grant R01GM65514. This minireview will be reprinted in the 2008 Minireview Compendium, which will be available in January, 2009.

¹ To whom correspondence should be addressed: Dept. of Medicine, Fox Chase Cancer Center, 333 Cottman Ave., Philadelphia, PA 19111. Tel.: 215-214-3956; Fax: 215-728-4333; E-mail: Greg.Enders{at}fccc.edu.

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