HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 283, Issue 3, 1211-1215, January 18, 2008

This Article Full Text Full Text (PDF) All Versions of this Article: 283/3/1211    most recent R700035200v1 Submit a Letter to Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hertel, K. J. Search for Related Content PubMed PubMed Citation Articles by Hertel, K. J. Social Bookmarking                      What's this?

Minireview

Combinatorial Control of Exon Recognition^*

From the Department of Microbiology and Molecular Genetics, University of California, Irvine, California 92697-4025

Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is carried out by the spliceosome, which catalyzes the removal of noncoding intronic sequences to assemble exons into mature mRNAs prior to export and translation. Given the complexity of higher eukaryotic genes and the relatively low level of splice site conservation, the precision of the splicing machinery in recognizing and pairing splice sites is impressive. Introns ranging in size from <100 up to 100,000 bases are removed efficiently. At the same time, a large number of alternative splicing events are observed between different cell types, during development, or during other biological processes. This extensive alternative splicing implies a significant flexibility of the spliceosome to identify and process exons within a given pre-mRNA. To reach this flexibility, splice site selection in higher eukaryotes has evolved to depend on multiple parameters such as splice site strength, the presence or absence of splicing regulators, RNA secondary structures, the exon/intron architecture, and the process of pre-mRNA synthesis itself. The relative contributions of each of these parameters control how efficiently splice sites are recognized and flanking introns are removed.

^* This minireview will be reprinted in the 2008 Minireview Compendium, which will be available in January, 2009. This work was supported by National Institutes of Health Grant GM 62287. This is the second article of five in the Alternative Splicing Minireview Series.

¹ To whom correspondence should be addressed: Dept. of Microbiology and Molecular Genetics, Med. Sci. I, Rm. 233, University of California, Irvine, CA 92697-4025. Tel.: 949-824-2127; Fax: 949-824-8598; E-mail: khertel{at}uci.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				A. D'Ambrogio, E. Buratti, C. Stuani, C. Guarnaccia, M. Romano, Y. M. Ayala, and F. E. Baralle Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo Nucleic Acids Res., July 1, 2009; 37(12): 4116 - 4126. [Abstract] [Full Text] [PDF]

				E. Wang and F. Cambi Heterogeneous Nuclear Ribonucleoproteins H and F Regulate the Proteolipid Protein/DM20 Ratio by Recruiting U1 Small Nuclear Ribonucleoprotein through a Complex Array of G Runs J. Biol. Chem., April 24, 2009; 284(17): 11194 - 11204. [Abstract] [Full Text] [PDF]

				M. V. Kotlajich, T. L. Crabb, and K. J. Hertel Spliceosome Assembly Pathways for Different Types of Alternative Splicing Converge during Commitment to Splice Site Pairing in the A Complex Mol. Cell. Biol., February 15, 2009; 29(4): 1072 - 1082. [Abstract] [Full Text] [PDF]

				K. L. Fox-Walsh and K. J. Hertel Splice-site pairing is an intrinsically high fidelity process PNAS, February 10, 2009; 106(6): 1766 - 1771. [Abstract] [Full Text] [PDF]

				H.-L. Zhou and H. Lou Repression of Prespliceosome Complex Formation at Two Distinct Steps by Fox-1/Fox-2 Proteins Mol. Cell. Biol., September 1, 2008; 28(17): 5507 - 5516. [Abstract] [Full Text] [PDF]

				P. J. Shepard and K. J. Hertel Conserved RNA secondary structures promote alternative splicing RNA, August 1, 2008; 14(8): 1463 - 1469. [Abstract] [Full Text] [PDF]

				D. Verma and S. Swaminathan Epstein-Barr Virus SM Protein Functions as an Alternative Splicing Factor J. Virol., July 15, 2008; 82(14): 7180 - 7188. [Abstract] [Full Text] [PDF]

				A. E. House and K. W. Lynch Regulation of Alternative Splicing: More than Just the ABCs J. Biol. Chem., January 18, 2008; 283(3): 1217 - 1221. [Abstract] [Full Text] [PDF]

				C. Ben-Dov, B. Hartmann, J. Lundgren, and J. Valcarcel Genome-wide Analysis of Alternative Pre-mRNA Splicing J. Biol. Chem., January 18, 2008; 283(3): 1229 - 1233. [Abstract] [Full Text] [PDF]

				M. J. Fedor Alternative Splicing Minireview Series: Combinatorial Control Facilitates Splicing Regulation of Gene Expression and Enhances Genome Diversity J. Biol. Chem., January 18, 2008; 283(3): 1209 - 1210. [Full Text] [PDF]