HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 283, Issue 3, 1217-1221, January 18, 2008

This Article Full Text Full Text (PDF) All Versions of this Article: 283/3/1217    most recent R700031200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by House, A. E. Articles by Lynch, K. W. Search for Related Content PubMed PubMed Citation Articles by House, A. E. Articles by Lynch, K. W. Social Bookmarking                      What's this?

Minireview

Regulation of Alternative Splicing: More than Just the ABCs^*

From the Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9038

Alternative pre-mRNA splicing, the differential inclusion or exclusion of portions of a nascent transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous mechanism for controlling protein expression. Thus, understanding the molecular basis of alternative splicing is essential for deciphering post-transcriptional control of the genome. Pre-mRNA splicing in general is catalyzed by a large dynamic macromolecular machine known as the spliceosome. Notably, the recognition of the intron substrate by spliceosomal components and the assembly of these components to form a catalytic spliceosome occur through a network of highly combinatorial molecular interactions. Many, if not all, of these interactions are subject to regulation, forming the basis of alternative splicing. This minireview focuses on recent advances in our understanding of the diversity of mechanisms by which the spliceosome can be regulated so as to achieve precise control of alternative splicing under a range of cellular conditions.

^* This minireview will be reprinted in the 2008 Minireview Compendium, which will be available in January, 2009. This is the third article of five in the Alternative Splicing Minireview Series.

¹ To whom correspondence should be addressed. Tel.: 214-648-2645; Fax: 214-648-8856; E-mail: kristen.lynch{at}utsouthwestern.edu.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				M. S. Marengo and D. A. Wassarman A DNA damage signal activates and derepresses exon inclusion in Drosophila TAF1 alternative splicing RNA, August 1, 2008; 14(8): 1681 - 1695. [Abstract] [Full Text] [PDF]

				Z. Wang and C. B. Burge Splicing regulation: From a parts list of regulatory elements to an integrated splicing code RNA, May 1, 2008; 14(5): 802 - 813. [Abstract] [Full Text] [PDF]

				C. Ben-Dov, B. Hartmann, J. Lundgren, and J. Valcarcel Genome-wide Analysis of Alternative Pre-mRNA Splicing J. Biol. Chem., January 18, 2008; 283(3): 1229 - 1233. [Abstract] [Full Text] [PDF]

				K. J. Hertel Combinatorial Control of Exon Recognition J. Biol. Chem., January 18, 2008; 283(3): 1211 - 1215. [Abstract] [Full Text] [PDF]

				M. J. Fedor Alternative Splicing Minireview Series: Combinatorial Control Facilitates Splicing Regulation of Gene Expression and Enhances Genome Diversity J. Biol. Chem., January 18, 2008; 283(3): 1209 - 1210. [Full Text] [PDF]