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J. Biol. Chem., Vol. 283, Issue 35, 24039-24046, August 29, 2008
Unlocking Repression of the Human Luteinizing Hormone Receptor Gene by Trichostatin A-induced Cell-specific Phosphatase Release*From the Section on Molecular Endocrinology, Endocrinology and Reproduction Research Branch, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver NICHD, National Institutes of Health, Bethesda, Maryland 20892-4510
Our previous studies demonstrated that the histone deacetylase inhibitor, trichostatin A (TSA), induces derepression of the human luteinizing hormone receptor (LHR) gene by de-recruitment of the pRB homologue p107 repressor from the promoter in JAR and MCF-7 cancer cells. TSA initiates a mechanism whereby the phosphatidylinositol 3-kinase/protein kinase
Received for publication, March 7, 2008 , and in revised form, July 1, 2008. * This work was supported, in whole or in part, by National Institutes of Health (Intramural Research Program of the NICHD). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. 1 To whom correspondence should be address: Bldg. 49, Rm. 6A-36, 49 Convent Dr., MSC 4510, National Institutes of Health, Bethesda, MD 20892-4510. Tel.: 301-496-2021; E-mail: dufaum{at}mail.nih.gov.
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