| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print January 5, 2001
J. Biol. Chem, 10.1074/jbc.C000569200
Submitted on August 21, 2000
Revised on January 5, 2001
Accepted on January 5, 2001
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02115
Corresponding Author: jmier{at}caregroup.harvard.edu
The caspase-8 homologue Flice Inhibitory Protein (FLIP) functions as a caspase-8 dominant negative, blocking apoptosis induced by the oligomerization of the adapter protein FADD/MORT-1. FLIP expression correlates with resistance to apoptosis induced by various members of the TNF family such as TRAIL. Furthermore, forced expression of FLIP renders cells resistant to fas-mediated apoptosis. Although FLIP expression is regulated primarily by MEK1 activity in activated T cells, the oncogenic signaling pathways that regulate FLIP expression in tumor cells are largely unknown. In this report, we examined the roles of the MAP kinase and PI3-kinase signaling pathways in the regulation of FLIP expression in tumor cells. We observed that the MEK1 inhibitor PD98059 reduced FLIP levels in only two of eleven tumor cell lines tested. In contrast, disruption of the PI3-kinase pathway with the specific inhibitor LY294002 reduced Akt (pkB) phosphorylation and the levels of FLIP protein and mRNA in all cell lines evaluated. The introduction of a dominant negative Akt adenoviral construct also consistently reduced FLIP expression as well as the phosphorylation of the Akt target glycogen synthase kinase-3. In addition, infection of the same cell lines with a constitutively active Akt adenovirus increased FLIP expression and the phosphorylation of GSK-3. These data add FLIP to the growing list of apoptosis inhibitors whose expression or function are regulated by the PI3-kinase-Akt pathway.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  X. Wang, W. Chen, W. Zeng, L. Bai, Y. Tesfaigzi, S. A. Belinsky, and Y. Lin Akt-mediated eminent expression of c-FLIP and Mcl-1 confers acquired resistance to TRAIL-induced cytotoxicity to lung cancer cells Mol. Cancer Ther., May 1, 2008; 7(5): 1156 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hewamana, S. Alghazal, T. T. Lin, M. Clement, C. Jenkins, M. L. Guzman, C. T. Jordan, S. Neelakantan, P. A. Crooks, A. K. Burnett, et al. The NF-{kappa}B subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target Blood, May 1, 2008; 111(9): 4681 - 4689. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Perez, N. Parquet, K. Shain, R. Nimmanapalli, M. Alsina, C. Anasetti, and W. Dalton Bone Marrow Stroma Confers Resistance to Apo2 Ligand/TRAIL in Multiple Myeloma in Part by Regulating c-FLIP J. Immunol., February 1, 2008; 180(3): 1545 - 1555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Chan, E. R. Bivins-Smith, M. S. Smith, and A. D. Yurochko Transcriptome Analysis of NF-{kappa}B- and Phosphatidylinositol 3-Kinase-Regulated Genes in Human Cytomegalovirus-Infected Monocytes J. Virol., January 15, 2008; 82(2): 1040 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Koschny, J. Sykora, H. Walczak, T. M. Ganten, T. L. Haas, M. R. Sprick, H. Holland, P. Ahnert, W. Krupp, J. Meixensberger, et al. Bortezomib-Mediated Up-Regulation of TRAIL-R1 and TRAIL-R2 Is Not Necessary for but Contributes to Sensitization of Primary Human Glioma Cells to TRAIL Clin. Cancer Res., November 1, 2007; 13(21): 6541 - 6542. [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. Cooper, A. Whaley-Connell, J. Habibi, Y. Wei, G. Lastra, C. Manrique, S. Stas, and J. R. Sowers Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2009 - H2023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. A. Elrod, Y.-D. Lin, P. Yue, X. Wang, S. Lonial, F. R. Khuri, and S.-Y. Sun The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway Mol. Cancer Ther., July 1, 2007; 6(7): 2029 - 2038. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chen, J. Xu, N. Jhala, P. Pawar, Z. B. Zhu, L. Ma, C.-H. Byon, and J. M. McDonald Fas-Mediated Apoptosis in Cholangiocarcinoma Cells Is Enhanced by 3,3'-Diindolylmethane through Inhibition of AKT Signaling and FLICE-Like Inhibitory Protein Am. J. Pathol., November 1, 2006; 169(5): 1833 - 1842. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Hu, C. Jiang, T. Schuster, G.-X. Li, P. T. Daniel, and J. Lu Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol. Cancer Ther., July 1, 2006; 5(7): 1873 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Lu, L. Wang, C. Stehlik, D. Medan, C. Huang, S. Hu, F. Chen, X. Shi, and Y. Rojanasakul Phosphatidylinositol 3-Kinase/Akt Positively Regulates Fas (CD95)-Mediated Apoptosis in Epidermal Cl41 Cells. J. Immunol., June 1, 2006; 176(11): 6785 - 6793. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Krueger, S. C. Fas, M. Giaisi, M. Bleumink, A. Merling, C. Stumpf, S. Baumann, D. Holtkotte, V. Bosch, P. H. Krammer, et al. HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP) Blood, May 15, 2006; 107(10): 3933 - 3939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Saito, K. Meyer, R. Warner, A. Basu, R. B. Ray, and R. Ray Hepatitis C Virus Core Protein Inhibits Tumor Necrosis Factor Alpha-Mediated Apoptosis by a Protective Effect Involving Cellular FLICE Inhibitory Protein J. Virol., May 1, 2006; 80(9): 4372 - 4379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Bertram, J. W. Peacock, C. Tan, A. L-F. Mui, S. W. Chung, M. E. Gleave, S. Dedhar, M. E. Cox, and C. J. Ong Inhibition of the Phosphatidylinositol 3'-Kinase Pathway Promotes Autocrine Fas-Induced Death of Phosphatase and Tensin Homologue-Deficient Prostate Cancer Cells. Cancer Res., May 1, 2006; 66(9): 4781 - 4788. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. C. Li, M. J. Park, S.-K. Ye, C.-W. Kim, and Y.-N. Kim Elevated Levels of Cholesterol-Rich Lipid Rafts in Cancer Cells Are Correlated with Apoptosis Sensitivity Induced by Cholesterol-Depleting Agents Am. J. Pathol., April 1, 2006; 168(4): 1107 - 1118. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Sampath, J. Cortes, Z. Estrov, M. Du, Z. Shi, M. Andreeff, V. Gandhi, and W. Plunkett Pharmacodynamics of cytarabine alone and in combination with 7-hydroxystaurosporine (UCN-01) in AML blasts in vitro and during a clinical trial Blood, March 15, 2006; 107(6): 2517 - 2524. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Oyarzo, L. J. Medeiros, C. Atwell, M. Feretzaki, V. Leventaki, E. Drakos, H. M. Amin, and G. Z. Rassidakis c-FLIP confers resistance to FAS-mediated apoptosis in anaplastic large-cell lymphoma Blood, March 15, 2006; 107(6): 2544 - 2547. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Jones, S. D. Saibil, J. M. Pun, A. R. Elford, M. Bonnard, M. Pellegrini, S. Arya, M. E. Parsons, C. M. Krawczyk, S. Gerondakis, et al. NF-{kappa}B Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo J. Immunol., September 15, 2005; 175(6): 3790 - 3799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Voelkel-Johnson, Y. A. Hannun, and A. El-Zawahry Resistance to TRAIL is associated with defects in ceramide signaling that can be overcome by exogenous C6-ceramide without requiring down-regulation of cellular FLICE inhibitory protein Mol. Cancer Ther., September 1, 2005; 4(9): 1320 - 1327. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Hu, C. Jiang, G. Li, and J. Lu PKB/AKT and ERK regulation of caspase-mediated apoptosis by methylseleninic acid in LNCaP prostate cancer cells Carcinogenesis, August 1, 2005; 26(8): 1374 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hashimoto, J. Nakajima-Shimada, and T. Aoki Trypanosoma cruzi Posttranscriptionally Up-Regulates and Exploits Cellular FLIP for Inhibition of Death-inducing Signal Mol. Biol. Cell, August 1, 2005; 16(8): 3521 - 3528. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Poukkula, A. Kaunisto, V. Hietakangas, K. Denessiouk, T. Katajamaki, M. S. Johnson, L. Sistonen, and J. E. Eriksson Rapid Turnover of c-FLIPshort Is Determined by Its Unique C-terminal Tail J. Biol. Chem., July 22, 2005; 280(29): 27345 - 27355. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. P. Beier, J. Wischhusen, M. Gleichmann, E. Gerhardt, A. Pekanovic, A. Krueger, V. Taylor, U. Suter, P. H. Krammer, M. Endres, et al. FasL (CD95L/APO-1L) Resistance of Neurons Mediated by Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B-Dependent Expression of Lifeguard/Neuronal Membrane Protein 35 J. Neurosci., July 20, 2005; 25(29): 6765 - 6774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Bremer, D. F. Samplonius, L. van Genne, M. H. Dijkstra, B. J. Kroesen, L. F. M. H. de Leij, and W. Helfrich Simultaneous Inhibition of Epidermal Growth Factor Receptor (EGFR) Signaling and Enhanced Activation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Receptor-mediated Apoptosis Induction by an scFv:sTRAIL Fusion Protein with Specificity for Human EGFR J. Biol. Chem., March 18, 2005; 280(11): 10025 - 10033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. X. Wu, J. La Rose, L. Chen, C. Neale, T. Mak, K. Okkenhaug, R. Wange, and R. Rottapel CD28 Regulates the Translation of Bcl-xL via the Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Pathway J. Immunol., January 1, 2005; 174(1): 180 - 194. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-E. Kim and S. R. Tannenbaum Insulin Regulates Cleavage of Procaspase-9 via Binding of X Chromosome-Linked Inhibitor of Apoptosis Protein in HT-29 Cells Cancer Res., December 15, 2004; 64(24): 9070 - 9075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, T.-G. Jin, H. Yang, W. C. DeWolf, R. Khosravi-Far, and A. F. Olumi Persistent c-FLIP(L) Expression Is Necessary and Sufficient to Maintain Resistance to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Mediated Apoptosis in Prostate Cancer Cancer Res., October 1, 2004; 64(19): 7086 - 7091. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Shah and P. W. Sylvester Tocotrienol-Induced Caspase-8 Activation Is Unrelated to Death Receptor Apoptotic Signaling in Neoplastic Mammary Epithelial Cells Experimental Biology and Medicine, September 1, 2004; 229(8): 745 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Nesterov, M. Nikrad, T. Johnson, and A. S. Kraft Oncogenic Ras Sensitizes Normal Human Cells to Tumor Necrosis Factor-{alpha}-Related Apoptosis-Inducing Ligand-Induced Apoptosis Cancer Res., June 1, 2004; 64(11): 3922 - 3927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suhara, K. Fukuo, O. Yasuda, M. Tsubakimoto, Y. Takemura, H. Kawamoto, T. Yokoi, M. Mogi, T. Kaimoto, and T. Ogihara Homocysteine Enhances Endothelial Apoptosis via Upregulation of Fas-Mediated Pathways Hypertension, June 1, 2004; 43(6): 1208 - 1213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Takemura, K. Fukuo, O. Yasuda, T. Inoue, N. Inomata, T. Yokoi, H. Kawamoto, T. Suhara, and T. Ogihara Fas Signaling Induces Akt Activation and Upregulation of Endothelial Nitric Oxide Synthase Expression Hypertension, April 1, 2004; 43(4): 880 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Wang, Y. Zhou, H. P. Kim, R. Song, R. Zarnegar, S. W. Ryter, and A. M. K. Choi Hepatocyte Growth Factor Protects against Hypoxia/Reoxygenation-induced Apoptosis in Endothelial Cells J. Biol. Chem., February 13, 2004; 279(7): 5237 - 5243. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C.-L. Hu, R. G. Cowan, R. M. Harman, and S. M. Quirk Cell Cycle Progression and Activation of Akt Kinase Are Required for Insulin-Like Growth Factor I-Mediated Suppression of Apoptosis in Granulosa Cells Mol. Endocrinol., February 1, 2004; 18(2): 326 - 338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Davies, J. Mason, M. J. O. Wakelam, L. S. Young, and A. G. Eliopoulos Inhibition of Phosphatidylinositol 3-Kinase- and ERK MAPK-regulated Protein Synthesis Reveals the Pro-apoptotic Properties of CD40 Ligation in Carcinoma Cells J. Biol. Chem., January 9, 2004; 279(2): 1010 - 1019. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Skurk, H. Maatz, H.-S. Kim, J. Yang, M. R. Abid, W. C. Aird, and K. Walsh The Akt-regulated Forkhead Transcription Factor FOXO3a Controls Endothelial Cell Viability through Modulation of the Caspase-8 Inhibitor FLIP J. Biol. Chem., January 9, 2004; 279(2): 1513 - 1525. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Q. Wang, T. Quan, T. He, T. F. Franke, J. J. Voorhees, and G. J. Fisher Epidermal Growth Factor Receptor-dependent, NF-{kappa}B-independent Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway Inhibits Ultraviolet Irradiation-induced Caspases-3, -8, and -9 in Human Keratinocytes J. Biol. Chem., November 14, 2003; 278(46): 45737 - 45745. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Panka and J. W. Mier Canstatin Inhibits Akt Activation and Induces Fas-dependent Apoptosis in Endothelial Cells J. Biol. Chem., September 26, 2003; 278(39): 37632 - 37636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kuenzi, P. Schneider, and D. A. E. Dobbelaere Theileria parva-Transformed T Cells Show Enhanced Resistance to Fas/Fas Ligand-Induced Apoptosis J. Immunol., August 1, 2003; 171(3): 1224 - 1231. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Asakuma, M. Sumitomo, T. Asano, T. Asano, and M. Hayakawa Selective Akt Inactivation and Tumor Necrosis Factor-related Apoptosis-inducing Ligand Sensitization of Renal Cancer Cells by Low Concentrations of Paclitaxel Cancer Res., March 15, 2003; 63(6): 1365 - 1370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Lee, Y. Park, J. K. Yoo, S. Y. Choi, and Y. C. Sung Inhibition of TCR-Induced CD8 T Cell Death by IL-12: Regulation of Fas Ligand and Cellular FLIP Expression and Caspase Activation by IL-12 J. Immunol., March 1, 2003; 170(5): 2456 - 2460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. F. Yang, C. Xiao, W. H. Roa, P. H. Krammer, and C. Hao Calcium/Calmodulin-dependent Protein Kinase II Regulation of c-FLIP Expression and Phosphorylation in Modulation of Fas-mediated Signaling in Malignant Glioma Cells J. Biol. Chem., February 21, 2003; 278(9): 7043 - 7050. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Nitobe, S. Yamaguchi, M. Okuyama, N. Nozaki, M. Sata, T. Miyamoto, Y. Takeishi, I. Kubota, and H. Tomoike Reactive oxygen species regulate FLICE inhibitory protein (FLIP) and susceptibility to Fas-mediated apoptosis in cardiac myocytes Cardiovasc Res, January 1, 2003; 57(1): 119 - 128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Li, M. S. Kluger, L. A. Madge, L. Zheng, A. L. M. Bothwell, and J. S. Pober Interferon-{gamma} Augments CD95(APO-1/Fas) and Pro-Caspase-8 Expression and Sensitizes Human Vascular Endothelial Cells to CD95-Mediated Apoptosis Am. J. Pathol., October 1, 2002; 161(4): 1485 - 1495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. G. Jones, A. R. Elford, M. J. Parsons, L. Wu, C. M. Krawczyk, W.-C. Yeh, R. Hakem, R. Rottapel, J. R. Woodgett, and P. S. Ohashi CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly J. Exp. Med., August 5, 2002; 196(3): 335 - 348. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Poulaki, C. S. Mitsiades, V. Kotoula, S. Tseleni-Balafouta, A. Ashkenazi, D. A. Koutras, and N. Mitsiades Regulation of Apo2L/Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Thyroid Carcinoma Cells Am. J. Pathol., August 1, 2002; 161(2): 643 - 654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Xiao, B. F. Yang, N. Asadi, F. Beguinot, and C. Hao Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Death-inducing Signaling Complex and Its Modulation by c-FLIP and PED/PEA-15 in Glioma Cells J. Biol. Chem., July 5, 2002; 277(28): 25020 - 25025. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Wang, N. Li, X. Wang, M. M. Kim, and B. M. Evers Augmentation of Sodium Butyrate-induced Apoptosis by Phosphatidylinositol 3'-Kinase Inhibition in the KM20 Human Colon Cancer Cell Line Clin. Cancer Res., June 1, 2002; 8(6): 1940 - 1947. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Lawlor and D. R. Alessi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci., March 10, 2002; 114(16): 2903 - 2910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. H. Shain, T. H. Landowski, and W. S. Dalton Adhesion-Mediated Intracellular Redistribution of c-Fas-Associated Death Domain-Like IL-1-Converting Enzyme-Like Inhibitory Protein-Long Confers Resistance to CD95-Induced Apoptosis in Hematopoietic Cancer Cell Lines J. Immunol., March 1, 2002; 168(5): 2544 - 2553. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Kelly, A. Won, Y. Refaeli, and L. V. Parijs IL-2 and Related Cytokines Can Promote T Cell Survival by Activating AKT J. Immunol., January 15, 2002; 168(2): 597 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Krueger, S. Baumann, P. H. Krammer, and S. Kirchhoff FLICE-Inhibitory Proteins: Regulators of Death Receptor-Mediated Apoptosis Mol. Cell. Biol., December 15, 2001; 21(24): 8247 - 8254. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Hatano and D. A. Brenner Akt protects mouse hepatocytes from TNF-alpha - and Fas-mediated apoptosis through NK-kappa B activation Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1357 - G1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Monick, R. K. Mallampalli, A. B. Carter, D. M. Flaherty, D. McCoy, P. K. Robeff, M. W. Peterson, and G. W. Hunninghake Ceramide Regulates Lipopolysaccharide-Induced Phosphatidylinositol 3-Kinase and Akt Activity in Human Alveolar Macrophages J. Immunol., November 15, 2001; 167(10): 5977 - 5985. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qiao, E. Studer, K. Leach, R. McKinstry, S. Gupta, R. Decker, R. Kukreja, K. Valerie, P. Nagarkatti, W. E. Deiry, et al. Deoxycholic Acid (DCA) Causes Ligand-independent Activation of Epidermal Growth Factor Receptor (EGFR) and FAS Receptor in Primary Hepatocytes: Inhibition of EGFR/Mitogen-activated Protein Kinase-Signaling Module Enhances DCA-induced Apoptosis Mol. Biol. Cell, September 1, 2001; 12(9): 2629 - 2645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Burns and W. S. El-Deiry Identification of Inhibitors of TRAIL-induced Death (ITIDs) in the TRAIL-sensitive Colon Carcinoma Cell Line SW480 Using a Genetic Approach J. Biol. Chem., October 5, 2001; 276(41): 37879 - 37886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Suhara, T. Mano, B. E. Oliveira, and K. Walsh Phosphatidylinositol 3-Kinase/Akt Signaling Controls Endothelial Cell Sensitivity to Fas-Mediated Apoptosis via Regulation of FLICE-Inhibitory Protein (FLIP) Circ. Res., July 6, 2001; 89(1): 13 - 19. [Abstract] [Full Text] [PDF]
|
|
