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C100315200v1
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Papers In Press, published online ahead of print July 11, 2001
J. Biol. Chem, 10.1074/jbc.C100315200
Submitted on June 11, 2001
Revised on July 9, 2001
Accepted on July 11, 2001

Steroid hormone receptor-mediated histone deacetylation and transcription at the mouse mammary tumor virus promoter

Lynn A. Sheldon, Matthias Becker, and Catharine L. Smith

Physiology, Dartmouth Medical School, Lebanon, NH 03756

Corresponding Author: Lynn.A.Sheldon{at}dartmouth.edu

Acetylation of lysines in histones H3 and H4 N-terminal tails is associated with transcriptional activation, and deacetylation with repression. Our studies with the mouse mammary virus (MMTV) promoter in chromatin show significant levels of acetylation at promoter proximal and distal regions prior to transactivation. Upon activation with glucocorticoids or progestins, promoter proximal histones become deacetylated within the region of inducible nuclease hypersensitivity. The deacetylation lags behind the initiation of transcription, indicating a role in post-activation regulation. Our results indicate a novel mechanism by which target promoters are regulated by steroid receptors and chromatin modification machinery.


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