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C200580200v1
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Papers In Press, published online ahead of print November 22, 2002
J. Biol. Chem, 10.1074/jbc.C200580200
Submitted on October 17, 2002
Revised on November 15, 2002
Accepted on November 22, 2002

The Escherichia coli copper-responsive copA promoter is activated by gold

Jivko V. Stoyanov and Nigel L. Brown

School of Biosciences, The University of Birmingham, Birmingham, W Midlands B15 2TT

Corresponding Author: n.l.brown{at}bham.ac.uk

The copA gene of E. coli encodes a copper transporter and its promoter is normally regulated by Cu(I) ions and CueR, a MerR-like transcriptional activator. We show that CueR can also be activated by gold salts and that Cys112 and Cys120 are involved in recognition of gold, silver and copper salts. Gold activation is unaffected by copper chelating agents but is affected by general metal chelators. This is the first example of specific regulation of transcription by gold and we briefly speculate that the biological effects of gold antiarthritic drugs may be through their effects on copper management in eukaryotic systems.


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