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C400035200v1
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Papers In Press, published online ahead of print January 26, 2004
J. Biol. Chem, 10.1074/jbc.C400035200
Submitted on January 20, 2004
Revised on January 26, 2004
Accepted on January 26, 2004

Identification of a role for beta -catenin in the establishment of a bipolar mitotic spindle

Daniel D. Kaplan, Thomas E. Meigs, Patrick Kelly, and Patrick J. Casey

Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC 27710

Corresponding Author: casey006{at}mc.duke.edu

beta -Catenin is a multifunctional protein that is known to participate in two well-defined cellular processes, cell-cell adhesion and Wnt-stimulated transcriptional activation. Here we report that beta -catenin participates in a third cellular process; the establishment of a bipolar mitotic spindle. During mitosis, beta -catenin re-localizes to mitotic spindle poles and to the midbody. Furthermore, biochemical fractionation demonstrates the presence of beta -catenin in purified centrosome preparations. Reduction of cellular beta -catenin by RNA interference leads to the failure of centrosomes to fully separate, resulting in a marked increase in the frequency of monoastral mitotic spindles. Our results define a new and important function for beta -catenin in mitosis and demonstrate that beta -catenin is involved in vital biological processes beyond cell adhesion and Wnt signaling.


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