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A more recent version of this article appeared on October 13, 2000
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Papers In Press, published online ahead of print July 17, 2000
J. Biol. Chem, 10.1074/jbc.M004613200
Submitted on May 28, 2000
Revised on July 13, 2000
Accepted on July 14, 2000

Identification and Characterization of Two Neuromedin U Receptors Differentially Expressed in Peripheral Tissues and the Central Nervous System

Rita Raddatz, Amy E. Wilson, Roman Artymyshyn, James A. Bonini, Beth Borowsky, Lakmal W. Boteju, Siqun Zhou, Evguenia V. Kouranova, Raisa Nagorny, Maricel S. Guevarra, Meng Dai, Gabriel S. Lerman, Pierre J. Vaysse, Theresa A. Branchek, Christophe Gerald, Carlos Forray, and Nika Adham

Department of Pharmacology, Synaptic Pharm Corp, Paramus, NJ 07652-1431

Corresponding Author: rraddatz{at}synapticcorp.com

Two structurally-related, G-protein coupled receptors were identified as receptors for the neuropeptide, Neuromedin U. This peptide is found in highest levels in the gut and genitourinary system where it potently contracts smooth muscle but is also expressed in the spinal cord and discrete regions of the brain. Binding sites for neuromedin U have been characterized in rat uterus, however little is known about the activity of this peptide in the regions of the central nervous where it is expressed. The receptors characterized in this report are activated by neuromedin U at nM potency in heterologous expression systems and bind radiolabeled neuromedin U with high affinity. Localization of the receptor RNA by quantitative RT-PCR in a variety of human tissues shows distinct expression patterns for the two receptors. NMU1 is expressed predominantly in peripheral tissues while NMU2 is more highly expressed in the central nervous system. Identification of neuromedin U receptor subtypes will greatly aid in the determination of the physiological roles of this peptide.


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