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Papers In Press, published online ahead of print September 7, 2000
Dept. of Biochemistry, University of Sydney, Sydney, NSW 2006
Corresponding Author: M.Crossley{at}biochem.usyd.edu.au
Members of the Ikaros family of transcription factors, Ikaros, Aiolos and Helios, are expressed in lymphocytes and have been implicated in controlling lymphoid development. These proteins contain two characteristic clusters of zinc fingers, an N-terminal domain important for DNA recognition, and a C-terminal domain that mediates homo- and heterotypic associations between family members. The conservation of these domains is such that all three proteins recognize related DNA sequences and all are capable of dimerizing with other family members. Here we describe two additional Ikaros family proteins, Eos and Pegasus. Eos is most highly related to Helios and shares its DNA-binding and protein association properties. Pegasus is related to other Ikaros proteins in its C-terminal dimerization domain, but contains a divergent N-terminal zinc finger domain. Pegasus self-associates and binds to other family members but recognizes distinct DNA-binding sites. Eos and Pegasus repress the expression of reporter genes containing their recognition elements. Our results suggest that these proteins may associate with previously described Ikaros family proteins in lymphoid cells and play additional roles in other tissues.
J. Biol. Chem, 10.1074/jbc.M005457200
Submitted on June 22, 2000
Revised on September 6, 2000
Accepted on September 7, 2000
Eos and Pegasus: two members of the Ikaros family of proteins with distinct DNA-binding activities
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