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Papers In Press, published online ahead of print November 21, 2000
J. Biol. Chem, 10.1074/jbc.M007939200
Submitted on August 30, 2000
Revised on November 20, 2000
Accepted on November 21, 2000
Nutrition, Case Western Reserve University School of Medicine, Cleveland, Oh 44106
Corresponding Author: dxm71{at}po.cwru.edu
To understand how glucose regulates the expression of the glucose-6-phosphatase gene, the effect of glucose was studied in primary cultures of rat hepatocytes. Glucose-6-phosphatase mRNA levels increased about 10-fold when hepatocytes were incubated with 20 mM glucose. The rate of transcription of the glucose-6-phosphatase gene, increased about 3-fold in hepatocytes incubated with glucose. The half-life of glucose-6-phosphatase mRNA was estimated to be 90 minutes in the absence of glucose and 3 h in its presence. Inhibition of the oxidative and the non-oxidative branches of the pentose phosphate pathway blocked the stimulation of glucose-6-phosphatase expression by glucose but not by xylitol or carbohydrates that enter the glycolytic/gluconeogenic pathways at the level of the Triose phosphates. These results indicate that i) the glucose induction of the mRNA for the catalytic unit of glucose-6-phosphatase occurs by transcriptional and post-transcriptional mechanisms, and that ii) xylitol and glucose increase the expression of this gene through different signaling pathways.
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