| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Papers In Press, published online ahead of print November 28, 2000
Biochemistry & Molecular Biology, Indiana University, Indianapolis, IN 46202-5121
Corresponding Author: mharrin{at}iupui.edu
The IL-1 receptor associated kinase (IRAK/mPLK) is linked to the regulation of NF-
J. Biol. Chem, 10.1074/jbc.M010399200
Submitted on November 16, 2000
Revised on November 28, 2000
Accepted on November 27, 2000
SIMPL is a Tumor Necrosis Factor specific regulator of NF-
B activity
B-dependent gene expression. Here we describe a novel binding partner of IRAK/mPLK that we term SIMPL (signaling molecule that associates with pelle-like kinase). Over-expression of SIMPL leads to activation of NF-B dependent promoters and inactivation of SIMPL inhibits IRAK/mPLK as well as TNF RI induced NF-B activity. Dominant-inhibitory alleles of IKK
or IKK
block the activation of NF-B by IRAK/mPLK and SIMPL. Furthermore SIMPL binds IRAK/mPLK and the IKKs in vitro and in vivo. In the presence of antisense mRNA to SIMPL, the physical association between IRAK/mPLK and IKK but not IRAK/mPLK and IKK is greatly diminished. Moreover dominant-negative SIMPL blocks IKK or IKK induced NF-B activity. These results lead us to propose a model in which SIMPL functions to regulate NF-B activity by linking IRAK/mPLK to IKK/ containing complexes.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. R. Conner, I. I. Smirnova, and A. Poltorak Forward genetic analysis of Toll-like receptor responses in wild-derived mice reveals a novel antiinflammatory role for IRAK1BP1 J. Exp. Med., February 18, 2008; 205(2): 305 - 314. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Luo, H.-J. Kwon, S. Montano, M. Georgiadis, M. G. Goebl, and M. A. Harrington Phosphorylation of SIMPL modulates RelA-associated NF-{kappa}B-dependent transcription Am J Physiol Cell Physiol, March 1, 2007; 292(3): C1013 - C1023. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-a Kim, D. C. Yeh, M. Ver, Y. Li, A. Carranza, T. P. Conrads, T. D. Veenstra, M. A. Harrington, and M. J. Quon Phosphorylation of Ser24 in the Pleckstrin Homology Domain of Insulin Receptor Substrate-1 by Mouse Pelle-like Kinase/Interleukin-1 Receptor-associated Kinase: CROSS-TALK BETWEEN INFLAMMATORY SIGNALING AND INSULIN SIGNALING THAT MAY CONTRIBUTE TO INSULIN RESISTANCE J. Biol. Chem., June 17, 2005; 280(24): 23173 - 23183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. C. Ziegler and S. Ghosh Regulating Inducible Transcription Through Controlled Localization Sci. Signal., May 17, 2005; 2005(284): re6 - re6. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Kwon, E. H. Breese, E. Vig-Varga, Y. Luo, Y. Lee, M. G. Goebl, and M. A. Harrington Tumor Necrosis Factor Alpha Induction of NF-{kappa}B Requires the Novel Coactivator SIMPL Mol. Cell. Biol., November 1, 2004; 24(21): 9317 - 9326. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K.-Y. Yu, H.-J. Kwon, D. A. M. Norman, E. Vig, M. G. Goebl, and M. A. Harrington Cutting Edge: Mouse Pellino-2 Modulates IL-1 and Lipopolysaccharide Signaling J. Immunol., October 15, 2002; 169(8): 4075 - 4078. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Mamidipudi, X. Li, and M. W. Wooten Identification of Interleukin 1 Receptor-associated Kinase as a Conserved Component in the p75-Neurotrophin Receptor Activation of Nuclear Factor-kappa B J. Biol. Chem., July 26, 2002; 277(31): 28010 - 28018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Starnes, H. E. Broxmeyer, M. J. Robertson, and R. Hromas Cutting Edge: IL-17D, a Novel Member of the IL-17 Family, Stimulates Cytokine Production and Inhibits Hemopoiesis J. Immunol., July 15, 2002; 169(2): 642 - 646. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
