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M104149200v1
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Papers In Press, published online ahead of print June 14, 2001
J. Biol. Chem, 10.1074/jbc.M104149200
Submitted on May 8, 2001
Revised on June 11, 2001
Accepted on June 14, 2001

A novel mouse b-defensin, mBD-6, predominantly expressed in skeletal muscle

Yasuhiro Yamaguchi, Shigetomo Fukuhara, Takahide Nagase, Tetsuji Tomita, Shigemi Hitomi, Satoshi Kimura, Hiroki Kurihara, and Yasuyoshi Ouchi

Embryogenesis, Kumamoto University, Kumamoto, Kumamoto 860-0811

Corresponding Author: kurihara{at}kaiju.medic.kumamoto-u.ac.jp

Defensins comprise a family of cationic antimicrobial peptides that is characterized by the conserved 6 cysteine residues. They are expressed in epithelial cells of various organs and are identified as key elements in the host defense system at the mucosal surface. We isolated a novel mouse b-defensin gene from the bacterial artificial chromosome DNA containing mouse b-defensin-3 gene. The full-length cDNA was cloned from skeletal muscle cDNA and termed mouse b-defensin-6 (mBD-6). The predicted peptide conserved a 6-cysteine motif and showed a microbicidal activity. The amino acid sequence had 59% identity with mouse b-defensin-3 and 59% identity with mouse b-defensin-4. mBD-6 showed very unique tissue specificity. We demonstrated the expression of mBD-6 in skeletal muscle in addition to the esophagus, tongue and trachea. In animal models of endotoxemia, mBD-6 expression was also induced in the lung. mBD-6 is the first reported b-defensin predominantly expressed in skeletal muscle, which indicates mBD-6 may play an important role in the regional defense mechanism in skeletal muscle against bacterial infection.


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